1-Boc-7-氮杂吲哚合成路线 （共 11 条）
反应条件
4-(N,N-dimethlyamino)pyridine in tetrahydrofuran T=20°C; 1 h;
参考文献
BETA PHARMA CANADA INC.; WANG, Zhaoyin
Patent: WO2013/53045 A1, 2013 ;
Location in patent: Paragraph 00145-00147 ;
反应条件
palladium diacetate; caesium carbonate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in toluene T=110°C; 6 h; Inert atmosphere;
参考文献
Hodgkinson, Roy C.; Schulz, Jurgen; Willis, Michael C.
Tetrahedron, 2009 , vol. 65, # 44 p. 8940 - 8949
反应条件
methanesulfonyl chloride; triethylamine in dichloromethane 0.0833333 h; Ambient temperature;
参考文献
Clark; Muchowski; Fisher; Flippin; Repke; Souchet
Synthesis, 1991 , # 10 p. 871 - 878
反应条件
1: tetrahydrofuran / Heating 2: 1) s-BuLi, 2) DMF / 1) THF, cyclohexane, -60 deg C 3: 92 percent / mesyl chloride, Et3N / CH2Cl2 / 0.08 h / Ambient temperature View Scheme
参考文献
Synthesis, , # 10 p. 871 - 878
反应条件
1: tetrahydrofuran / Heating 2: 1) s-BuLi, 2) DMF / 1) THF, cyclohexane, -60 deg C 3: 92 percent / mesyl chloride, Et3N / CH2Cl2 / 0.08 h / Ambient temperature View Scheme
参考文献
Synthesis, , # 10 p. 871 - 878
反应条件
1: 1) s-BuLi, 2) DMF / 1) THF, cyclohexane, -60 deg C 2: 92 percent / mesyl chloride, Et3N / CH2Cl2 / 0.08 h / Ambient temperature View Scheme
参考文献
Synthesis, , # 10 p. 871 - 878
反应条件
bis(η4-1,5-cyclooctadiene)-di-μ-methoxy-diiridium(I); 4,4'-di-tert-butyl-2,2'-dipyridyl in hexane T=20°C; 5 h; Inert atmosphere; regioselective reaction;
参考文献
Kallepalli, Venkata A.; Shi, Feng; Paul, Sulagna; Onyeozili, Edith N.; Maleczka Jr., Robert E.; Smith III, Milton R.
Journal of Organic Chemistry, 2009 , vol. 74, # 23 p. 9199 - 9201
反应条件
bis(η4-1,5-cyclooctadiene)-di-μ-methoxy-diiridium(I); 3,4,7,8-tetra-methyl-1,10-phenanthroline in tetrahydrofuran T=80°C; 19 h; Inert atmosphereGlovebox;
参考文献
Larsen, Matthew A.; Hartwig, John F.
Journal of the American Chemical Society, 2014 , vol. 136, # 11 p. 4287 - 4299
反应条件
1: 4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl-4',4',5',5'-tetramethyl-1,3,2-dioxaborolane With bis(η4-1,5-cyclooctadiene)-di-μ-methoxy-diiridium(I); 4,4'-di-tert-butyl-2,2'-dipyridyl in tert-butyl methyl ether
Inert atmosphere;
2: N-Boc-7-azaindole in tert-butyl methyl ether
T=80°C; 0.333333 h; Inert atmosphereMicrowave irradiation;
参考文献
Harrisson, Peter; Morris, James; Marder, Todd B.; Steel, Patrick G.
Organic Letters, 2009 , vol. 11, # 16 p. 3586 - 3589
反应条件
bis(η4-1,5-cyclooctadiene)-di-μ-methoxy-diiridium(I); 4,4'-di-tert-butyl-2,2'-dipyridyl in hexane
T=20°C; 96 h; Inert atmosphere; regioselective reaction;
参考文献
Kallepalli, Venkata A.; Shi, Feng; Paul, Sulagna; Onyeozili, Edith N.; Maleczka Jr., Robert E.; Smith III, Milton R.
Journal of Organic Chemistry, 2009 , vol. 74, # 23 p. 9199 - 9201
