1-(叔丁氧基羰基)-6-甲氧基吲哚合成路线 （共 7 条）
反应条件
4-(N,N-dimethlyamino)pyridine in dichloromethane T=20°C; 8 h; Inert atmosphere;
参考文献
Zhou, Jiao-Long; Ye, Meng-Chun; Sun, Xiu-Li; Tang, Yong
Tetrahedron, 2009 , vol. 65, # 34 p. 6877 - 6881
反应条件
hydrogenchloride in tetrahydrofuran 0.0833333 h; Ambient temperature; Yield given;
参考文献
Synthesis, , # 10 p. 871 - 878
反应条件
1: tetrahydrofuran / Heating 2: 1a) s-BuLi, 2) DMF / 1a) THF, cyclohexane, -45 to -55 deg C, 30 min, 1b) -> -15 deg C, 60 min, 2) -45 deg C, 5 min 3: 12N HCl / tetrahydrofuran / 0.08 h / Ambient temperature View Scheme
参考文献
Synthesis, , # 10 p. 871 - 878
反应条件
1: 1a) s-BuLi, 2) DMF / 1a) THF, cyclohexane, -45 to -55 deg C, 30 min, 1b) -> -15 deg C, 60 min, 2) -45 deg C, 5 min 2: 12N HCl / tetrahydrofuran / 0.08 h / Ambient temperature View Scheme
参考文献
Synthesis, , # 10 p. 871 - 878
反应条件
1: tetrahydrofuran / Heating 2: 1a) s-BuLi, 2) DMF / 1a) THF, cyclohexane, -45 to -55 deg C, 30 min, 1b) -> -15 deg C, 60 min, 2) -45 deg C, 5 min 3: 12N HCl / tetrahydrofuran / 0.08 h / Ambient temperature View Scheme
参考文献
Synthesis, , # 10 p. 871 - 878
反应条件
sodium hydroxide in ethanol 1 h; Heating;
参考文献
Clark; Muchowski; Fisher; Flippin; Repke; Souchet
Synthesis, 1991 , # 10 p. 871 - 878
反应条件
1: With tri-isopropoxy-borane; lithium diisopropyl amide in tetrahydrofuran; cyclohexane T=0 - 20°C; 0.75 h; 2: With hydrogenchloride; water in tetrahydrofuran; cyclohexane
参考文献
PTC THERAPEUTICS, INC.; HWANG, Peter Seongwoo; TAKASUGI, James; REN, Hongyu; WILDE, Richard Gerald; TURPOFF, Anthony; AREFOLOV, Alexander; KARP, Gary Mitchell; CHEN, Guangming; CAMPBELL, Jeffrey Allen
Patent: WO2006/19831 A1, 2006 ;
Location in patent: Page/Page column 450 ;
