N-[(2-甲基苯基)甲基]氨基甲酸1,1-二甲基乙酯合成路线 （共 11 条）
反应条件
palladium diacetate; potassium carbonate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in water; toluene T=85°C; Suzuki-Miyaura cross-coupling reaction; 22 h; Inert atmosphere;
参考文献
Molander, Gary A.; Shin, Inji
Organic Letters, 2011 , vol. 13, # 15 p. 3956 - 3959
反应条件
potassium phosphate; dichloro(cycloocta-1,5-diene)palladium(II); dicyclohexyl(2',6'-diisopropoxy-[1,1'-biphenyl]-2-yl)phosphine in water; tert-butyl alcohol T=95°C; Suzuki-Miyaura cross-coupling; 22 h; Inert atmosphere;
参考文献
Molander, Gary A.; Shin, Inji
Organic Letters, 2012 , vol. 14, # 12 p. 3138 - 3141
反应条件
C45H59ClNPPd; potassium carbonate in water; tert-butyl alcohol T=85°C; Suzuki-Miyaura Coupling; 3 h; Inert atmosphere;
参考文献
Molander, Gary A.; Shin, Inji
Organic Letters, 2013 , vol. 15, # 10 p. 2534 - 2537
反应条件
in tetrahydrofuran 4 h; Ambient temperature;
参考文献
Clark; Jahangir; Langston
Canadian Journal of Chemistry, 1994 , vol. 72, # 1 p. 23 - 30
反应条件
1.1: potassium hexamethylsilazane / tetrahydrofuran / 2.25 h / -78 - 20 °C 1.2: 1 h / 0 °C 1.3: 0 - 20 °C 2.1: KHF2 / methanol; water / 0 - 20 °C 3.1: palladium diacetate; potassium carbonate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl / water; toluene / 22 h / 85 °C / Inert atmosphere View Scheme
参考文献
Molander, Gary A.; Shin, Inji
Organic Letters, 2011 , vol. 13, # 15 p. 3956 - 3959
反应条件
sec.-butyllithium 1.) THF, cyclohexane, -35 deg C, 2.) THF, cyclohexane; Yield given. Multistep reaction;
参考文献
Clark, Robin D.; Jahangir
Heterocycles, 1991 , vol. 32, # 9 p. 1699 - 1703
反应条件
Yield given. Multistep reaction;
参考文献
Clark, Robin D.; Jahangir
Tetrahedron, 1993 , vol. 49, # 7 p. 1351 - 1356
反应条件
1: 1.) sec-BuLi / 1.) THF, cyclohexane, -30 deg C, 10 min, 2.) THF, cyclohexane 2: 95 percent / conc. HCl / tetrahydrofuran / 0.17 h / Ambient temperature 3: 95 percent / H2 / Pd(OH)2 / ethyl acetate / 12 h / 2585.7 Torr View Scheme
参考文献
Clark, Robin D.; Jahangir
Heterocycles, 1991 , vol. 32, # 9 p. 1699 - 1703
反应条件
1: 1.) sec-BuLi / 1.) THF, cyclohexane, -35 deg C, 2.) THF, cyclohexane 2: 70 percent / HCl / ethanol View Scheme
参考文献
Clark, Robin D.; Jahangir
Heterocycles, 1991 , vol. 32, # 9 p. 1699 - 1703
反应条件
1: 1.) sec-BuLi / 1.) THF, cyclohexane, -30 deg C, 10 min, 2.) THF, cyclohexane, from -60 to -30 deg C, 0.5 h
2: 92 percent / CF3COOH / CH2Cl2 / 0.5 h / 0 - 20 °C
3: 98 percent / H2 / Pd(OH)2 / ethyl acetate / 12 h / 2327.2 Torr
4: 1.) CF3COOH, 2.) aq. NaHCO3 / 1.) CH2Cl2, RT, 2 h
View Scheme
参考文献
Clark, Robin D.; Jahangir
Heterocycles, 1991 , vol. 32, # 9 p. 1699 - 1703
