1: N-{3-chloro-4-[(3-fluoro-benzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)furan-2-yl]quinazoline-4-amine hydrochloride With sodium hydroxide in water; ethyl acetate pH=10; Inert atmosphere; 2: toluene-4-sulfonic acid in N,N-dimethyl-formamide T=40°C; 1 h;