(S)-2-n-boc-氨基-1-吡咯烷-1-基-1-丙酮合成路线 （共 5 条）
反应条件
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane 4 h; Ambient temperature;
参考文献
De Costa; Radesca; Di Paolo; Bowen
Journal of Medicinal Chemistry, 1992 , vol. 35, # 1 p. 38 - 47
反应条件
1: N-methylmorpholine / CH2Cl2 / 0.33 h / -15 °C 2: CH2Cl2 / 1 h / -15 °C View Scheme
参考文献
Wallen, Erik A. A.; Christiaans, Johannes A. M.; Jarho, Elina M.; Forsberg, Markus M.; Venaelaeinen, Jarkko I.; Maennistoe, Pekka T.; Gynther, Jukka
Journal of Medicinal Chemistry, 2003 , vol. 46, # 21 p. 4543 - 4551
反应条件
in dichloromethane T=-15°C; 1 h;
参考文献
Xu, Yongmei; Cordova, Armando
Chemical Communications, 2006 , # 4 p. 460 - 462
反应条件
in tetrahydrofuran T=20°C;
参考文献
Wallen, Erik A. A.; Christiaans, Johannes A. M.; Jarho, Elina M.; Forsberg, Markus M.; Venaelaeinen, Jarkko I.; Maennistoe, Pekka T.; Gynther, Jukka
Journal of Medicinal Chemistry, 2003 , vol. 46, # 21 p. 4543 - 4551
反应条件
tris(2,2,2-trifluoroethyl) borate in acetonitrile T=100°C; 24 h; Sealed tube; Overall yield = 59percent; Overall yield = 135 mg;
参考文献
Lanigan, Rachel M.; Starkov, Pavel; Sheppard, Tom D.
Journal of Organic Chemistry, 2013 , vol. 78, # 9 p. 4512 - 4523
