N-叔丁氧羰基-N'-甲苯磺酰基-L-精氨酸合成路线 （共 22 条）
反应条件
1: tetrahydrofuran; H2O / 4 h / 60 °C 2: 89 percent / Celite; AgNO3; NH3 / acetonitrile / 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 40, # 23 p. 4439 - 4442
反应条件
1: BOC-glycine; C14H14NPol With benzotriazol-1-ol; diisopropyl-carbodiimide in N,N-dimethyl-formamide solid phase reaction; 2: With trifluoroacetic acid in dichloromethane 0.5 h; solid phase reaction; 3: BOC-glycine; 1-(tert-butoxycarbonyl)-L-proline; N-tert-butoxycarbonyl-L-leucine; boc-Ng-tosyl-L-arginine; N-tert-butoxycarbonyl-O-benzyl-L-serine; Boc-L-tyrosine(2-Br-Z)-OH; boc-Trp(CHO)-OH; Boc-pGlu-OH; N-Boc-L-His(Tos)-OH Further stages;
参考文献
Nakaie, Clovis R.; Oliveira, Eliandre; Vicente, Eduardo F.; Jubilut, Guita N.; Souza, Sinval E.G.; Marchetto, Reinaldo; Cilli, Eduardo M.
Bioorganic Chemistry, 2011 , vol. 39, # 2 p. 101 - 109
反应条件
Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Nishino, Norikazu; Xu, Ming; Mihara, Hisakazu; Fujimoto, Tsutomu; Ueno, Yukio; Kumagai, Hiromichi
Tetrahedron Letters, 1992 , vol. 33, # 11 p. 1479 - 1482
反应条件
Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Nishino, Norikazu; Xu, Ming; Mihara, Hisakazu; Fujimoto, Tsutomu; Ueno, Yukio; Kumagai, Hiromichi
Tetrahedron Letters, 1992 , vol. 33, # 11 p. 1479 - 1482
反应条件
1: DCC / tetrahydrofuran / 0 °C 2: 83 percent / 4-methylmorpholine / tetrahydrofuran / 30 h / 20 °C 3: 85 percent / Me2S; CF3COOH; CF3SO3H / methoxybenzene / 0 °C View Scheme
参考文献
Zhao, Ming; Peng, Shiqi
Advanced Synthesis and Catalysis, 1999 , vol. 341, # 7 p. 668 - 676
反应条件
1: C21H31N2O5Pol With trifluoroacetic acid in dichloromethane 0.5 h; solid phase reaction; 2: N-Boc-L-His(Tos)-OH With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine in 1-methyl-pyrrolidin-2-one; dimethyl sulfoxide 3 h; solid phase reaction; 3: 1-(tert-butoxycarbonyl)-L-proline; t-Boc-L-valine; (2S,3S)-2-(tert-butoxycarbonylamino)-3-methylpentanoic acid; N-tert-butoxycarbonyl-L-phenylalanine; boc-Ng-tosyl-L-arginine; (2S)-3-cyclohexyloxycarbonyl-2-t-butoxycarbonylaminopropanoic acid; Boc-L-tyrosine(2-Br-Z)-OH; N-Boc-L-His(Tos)-OH Further stages;
参考文献
Nakaie, Clovis R.; Oliveira, Eliandre; Vicente, Eduardo F.; Jubilut, Guita N.; Souza, Sinval E.G.; Marchetto, Reinaldo; Cilli, Eduardo M.
Bioorganic Chemistry, 2011 , vol. 39, # 2 p. 101 - 109
反应条件
1: C24H29N2O5Pol With trifluoroacetic acid in dichloromethane 0.5 h; solid phase reaction; 2: 1-(tert-butoxycarbonyl)-L-proline With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine in 1-methyl-pyrrolidin-2-one; dimethyl sulfoxide 3 h; solid phase reaction; 3: t-Boc-L-valine; (2S,3S)-2-(tert-butoxycarbonylamino)-3-methylpentanoic acid; boc-Ng-tosyl-L-arginine; (2S)-3-cyclohexyloxycarbonyl-2-t-butoxycarbonylaminopropanoic acid; Boc-L-tyrosine(2-Br-Z)-OH; N-Boc-L-His(Tos)-OH Further stages;
参考文献
Nakaie, Clovis R.; Oliveira, Eliandre; Vicente, Eduardo F.; Jubilut, Guita N.; Souza, Sinval E.G.; Marchetto, Reinaldo; Cilli, Eduardo M.
Bioorganic Chemistry, 2011 , vol. 39, # 2 p. 101 - 109
反应条件
water T=170°C; 0.05 h; Microwave irradiation;
参考文献
Thaqi, Ali; McCluskey, Adam; Scott, Janet L.
Tetrahedron Letters, 2008 , vol. 49, # 49 p. 6962 - 6964
反应条件
phenylthio(trimethyl)silane; pertrimethylsilylated Nafion; 3-methyl-phenol; trifluoroacetic acid 3 h;
参考文献
Petrakis, K. S.; Kaiser, Emil Thomas; Oesapay, George
Journal of the Chemical Society, Chemical Communications, 1991 , # 7 p. 530 - 531
反应条件
1: 293.3 mg 2: 188 mg / K3Fe(CN)6 / H2O; acetonitrile / 2 h / pH 8.5 View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 4 p. 569 - 580
