N-ethyl-N,N-diisopropylamine; 1,1'-bis-(diphenylphosphino)ferrocene; bis(benzonitrile)palladium(II) dichloride T=135°C; P=11251.1 Torr; 4 h;

1.1: hydrogenchloride / water / 4 h / Reflux 2.1: acetic acid; iron / 2 h / Reflux 3.1: triethylamine / dichloromethane / 18 h 3.2: 1 h 4.1: acetic anhydride; potassium acetate; acetic acid; isopentyl nitrite / toluene / 3 h / Reflux 5.1: potassium carbonate; methanol / 1 h / Reflux 6.1: N-ethyl-N,N-diisopropylamine / bis(benzonitrile)palladium(II) dichloride; 1,1'-bis-(diphenylphosphino)ferrocene / 4 h / 135 °C / 11251.1 Torr View Scheme

1.1: acetic acid; iron / 2 h / Reflux 2.1: triethylamine / dichloromethane / 18 h 2.2: 1 h 3.1: acetic anhydride; potassium acetate; acetic acid; isopentyl nitrite / toluene / 3 h / Reflux 4.1: potassium carbonate; methanol / 1 h / Reflux 5.1: N-ethyl-N,N-diisopropylamine / bis(benzonitrile)palladium(II) dichloride; 1,1'-bis-(diphenylphosphino)ferrocene / 4 h / 135 °C / 11251.1 Torr View Scheme

1.1: triethylamine / dichloromethane / 18 h 1.2: 1 h 2.1: acetic anhydride; potassium acetate; acetic acid; isopentyl nitrite / toluene / 3 h / Reflux 3.1: potassium carbonate; methanol / 1 h / Reflux 4.1: N-ethyl-N,N-diisopropylamine / bis(benzonitrile)palladium(II) dichloride; 1,1'-bis-(diphenylphosphino)ferrocene / 4 h / 135 °C / 11251.1 Torr View Scheme

1: acetic anhydride; potassium acetate; acetic acid; isopentyl nitrite / toluene / 3 h / Reflux 2: potassium carbonate; methanol / 1 h / Reflux 3: N-ethyl-N,N-diisopropylamine / bis(benzonitrile)palladium(II) dichloride; 1,1'-bis-(diphenylphosphino)ferrocene / 4 h / 135 °C / 11251.1 Torr View Scheme

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / -10 °C 1.2: 4 h 2.1: hydrogenchloride / water / 4 h / Reflux 3.1: acetic acid; iron / 2 h / Reflux 4.1: triethylamine / dichloromethane / 18 h 4.2: 1 h 5.1: acetic anhydride; potassium acetate; acetic acid; isopentyl nitrite / toluene / 3 h / Reflux 6.1: potassium carbonate; methanol / 1 h / Reflux 7.1: N-ethyl-N,N-diisopropylamine / bis(benzonitrile)palladium(II) dichloride; 1,1'-bis-(diphenylphosphino)ferrocene / 4 h / 135 °C / 11251.1 Torr View Scheme

1: potassium carbonate; methanol / 1 h / Reflux 2: N-ethyl-N,N-diisopropylamine / bis(benzonitrile)palladium(II) dichloride; 1,1'-bis-(diphenylphosphino)ferrocene / 4 h / 135 °C / 11251.1 Torr View Scheme