1: triethylamine / CH2Cl2 / 1 h / Ambient temperature 2: 1.) lithium hexamethyldisilazide / 1.) THF, -78 deg C, 15 min, 2.) THF, -78 deg C, 10 min 3: LiOH*H2O / tetrahydrofuran / 18 h / Ambient temperature View Scheme

1: HCl (g) / ethyl acetate / 0.5 h / 12 °C 2: triethylamine / CH2Cl2 / 1 h / Ambient temperature 3: 1.) lithium hexamethyldisilazide / 1.) THF, -78 deg C, 15 min, 2.) THF, -78 deg C, 10 min 4: LiOH*H2O / tetrahydrofuran / 18 h / Ambient temperature View Scheme

1: triethylamine / CH2Cl2 / 1 h / Ambient temperature 2: 1.) lithium hexamethyldisilazide / 1.) THF, -78 deg C, 15 min, 2.) THF, -78 deg C, 10 min 3: LiOH*H2O / tetrahydrofuran / 18 h / Ambient temperature View Scheme

1: 1.) lithium hexamethyldisilazide / 1.) THF, -78 deg C, 15 min, 2.) THF, -78 deg C, 10 min 2: LiOH*H2O / tetrahydrofuran / 18 h / Ambient temperature View Scheme