N(6)-[乙基[[4-(哌嗪基磺酰基]苄基]]-6-氨基苯并(cd)吲哚-2(1H)-酮合成路线 （共 6 条）
反应条件
hydrogenchloride in methanol Ambient temperature;
参考文献
Varney, Michael D.; Marzoni, Gifford P.; Palmer, Cindy L.; Deal, Judith G.; Webber, Stephanie; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 4 p. 663 - 676
反应条件
1: 53 percent / DIEA / tetrahydrofuran / 1 h 2: 91 percent / K2CO3 / dimethylformamide / 0.33 h 3: 93 percent / 1 M DIBAL / tetrahydrofuran; hexane / 0.5 h 4: 96 percent / Ph3P, CBr4 / CH2Cl2 / 0.33 h 5: 47 percent / K2CO3 / dimethylformamide / 100 °C 6: 94 percent / HCl / methanol / Ambient temperature View Scheme
参考文献
Varney, Michael D.; Marzoni, Gifford P.; Palmer, Cindy L.; Deal, Judith G.; Webber, Stephanie; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 4 p. 663 - 676
反应条件
1: K2CO3 / dimethylformamide / 8 h / 70 - 100 °C 2: 47 percent / K2CO3 / dimethylformamide / 100 °C 3: 94 percent / HCl / methanol / Ambient temperature View Scheme
参考文献
Varney, Michael D.; Marzoni, Gifford P.; Palmer, Cindy L.; Deal, Judith G.; Webber, Stephanie; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 4 p. 663 - 676
反应条件
1: 96 percent / Ph3P, CBr4 / CH2Cl2 / 0.33 h 2: 47 percent / K2CO3 / dimethylformamide / 100 °C 3: 94 percent / HCl / methanol / Ambient temperature View Scheme
参考文献
Varney, Michael D.; Marzoni, Gifford P.; Palmer, Cindy L.; Deal, Judith G.; Webber, Stephanie; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 4 p. 663 - 676
反应条件
1: 91 percent / K2CO3 / dimethylformamide / 0.33 h 2: 93 percent / 1 M DIBAL / tetrahydrofuran; hexane / 0.5 h 3: 96 percent / Ph3P, CBr4 / CH2Cl2 / 0.33 h 4: 47 percent / K2CO3 / dimethylformamide / 100 °C 5: 94 percent / HCl / methanol / Ambient temperature View Scheme
参考文献
Varney, Michael D.; Marzoni, Gifford P.; Palmer, Cindy L.; Deal, Judith G.; Webber, Stephanie; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 4 p. 663 - 676
反应条件
1: 93 percent / 1 M DIBAL / tetrahydrofuran; hexane / 0.5 h 2: 96 percent / Ph3P, CBr4 / CH2Cl2 / 0.33 h 3: 47 percent / K2CO3 / dimethylformamide / 100 °C 4: 94 percent / HCl / methanol / Ambient temperature View Scheme
参考文献
Varney, Michael D.; Marzoni, Gifford P.; Palmer, Cindy L.; Deal, Judith G.; Webber, Stephanie; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 4 p. 663 - 676
