4-([4-(溴甲基)苯基]磺酰基)吗啉合成路线 （共 4 条）
反应条件
1: morpholine With triethylamine in diethyl ether T=0°C; Inert atmosphere; 2: 4-(Bromomethyl)benzenesulfonyl Chloride in diethyl ether T=20°C; 6 h; Inert atmosphere;
参考文献
Tsoi, Yuk-Tai; Zhou, Zhongyuan; Yu, Wing-Yiu
Organic Letters, 2011 , vol. 13, # 19 p. 5370 - 5373
反应条件
N-bromosuccinmide in tetrachloromethane 4 h; Reflux;
参考文献
Kafle, Bhooshan; Bhattarai, Bharat Raj; Cho, Hyeongjin
Bulletin of the Korean Chemical Society, 2011 , vol. 32, # 1 p. 31 - 32
反应条件
1: 99 percent / CH2Cl2 / 2 h / 0 °C 2: 48 percent / NBS / CCl4 / 1 h / Heating; Irradiation View Scheme
参考文献
Kafle, Bhooshan; Bhattarai, Bharat Raj; Cho, Hyeongjin
Bulletin of the Korean Chemical Society, 2011 , vol. 32, # 1 p. 31 - 32
反应条件
1: 75 percent / DIEA / dimethylformamide / a) 105 deg C, 1.5 h, b) 85 deg C, 1.5 h
2: 59 percent / DIEA / dimethylformamide / 1.42 h / 75 °C
3: Lawesson's reagent / toluene
4: NaOH / tetrahydrofuran; ethanol
5: NH3 / methanol
View Scheme
参考文献
Varney, Michael D.; Marzoni, Gifford P.; Palmer, Cindy L.; Deal, Judith G.; Webber, Stephanie; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 4 p. 663 - 676
