1: 99 percent / potassium azodicarboxylate, AcOH / methanol / 1 h / Ambient temperature 2: 0.1 N TFA / tetrahydrofuran / 4 h / Ambient temperature View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1209227', constants.ctx, '0')">n-butyllithium</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '1730733', constants.ctx, '0')">hexane</a> <br />T=-70&deg;C;&nbsp;6&nbsp;h;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 1) n-BuLi / 1) hexane, THF, -70 deg C, 15 min, 2) 4 h<br />2: 62 percent / n-BuLi / tetrahydrofuran; hexane / 6 h / -70 &deg;C<br /> <br /> &nbsp;