2-丁基-1,3-二氮杂螺环-[4,4]壬-1-烯-4酮合成路线 （共 9 条）
反应条件
acetic acid in xylene 6.5 h; Heating;
参考文献
Bernhart, Claude A.; Perreaut, Pierre M.; Ferrari, Bernard P.; Muneaux, Yvette A.; Assens, Jean-Louis A.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 22 p. 3371 - 3380
反应条件
potassium hydroxide in tetrahydrofuran; methanol; water 2.5 h; Heating / reflux;
参考文献
Sanofi-Synthelabo
Patent: US6800761 B1, 2004 ;
Location in patent: Page column 7 ;
反应条件
5 Pd(II)/C(eggshell) in methanol 24 h; Reflux;
参考文献
Panov, Illia; Drabina, Pavel; Padelkova, Zdenka; Hanusek, Jiri; Sedlak, Milos
Journal of Heterocyclic Chemistry, 2010 , vol. 47, # 6 p. 1356 - 1360
反应条件
potassium hydroxide in tetrahydrofuran; methanol 2.5 h; Heating;
参考文献
Cousaert, Nicolas; Willand, Nicolas; Gesquiere, Jean-Claude; Tartar, Andre; Deprez, Benoit; Deprez-Poulain, Rebecca
Tetrahedron Letters, 2008 , vol. 49, # 17 p. 2743 - 2747
反应条件
1: With triethylamine in toluene T=20 - 80°C; 2: With potassium hydroxide; dihydrogen peroxide in methanol; water 2.5 h; Heating; Further stages.;
参考文献
Kavitha; Gaonkar; Narendra Sharath Chandra; Sadashiva; Rangappa
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 23 p. 7391 - 7398
反应条件
1: 1.) NaH / 1.) DMF, RT, 0.5 h, 2.) DMF, RT, 1 h 2: 68 percent / Bu3SnN3 / xylene / 88 h / Heating View Scheme
参考文献
Bernhart, Claude A.; Perreaut, Pierre M.; Ferrari, Bernard P.; Muneaux, Yvette A.; Assens, Jean-Louis A.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 22 p. 3371 - 3380
反应条件
potassium hydroxide; tetrabutylammomium bromide in acetonitrile T=31 - 40°C; 2.5 h; Product distribution / selectivity;
参考文献
KRKA, TOVARNA ZDRAVIL, D.D., NOVO MESTO
Patent: WO2006/73376 A2, 2006 ;
Location in patent: Page/Page column 10-11 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide T=26°C; 8 h;
参考文献
Kumar, Manian Rajesh; Park, Kyungho; Lee, Sunwoo
Advanced Synthesis and Catalysis, 2010 , vol. 352, # 18 p. 3255 - 3266
反应条件
1: 2-butyl-1,3-diaza-spiro[4.4]non-1-en-4-one With sodium hydride in DMF (N,N-dimethyl-formamide) T=20°C; 0.5 h; 2: 4-bromomethyl-biphenyl-2-carbonitrile in DMF (N,N-dimethyl-formamide) T=20°C; 1 h;
参考文献
Sanofi-Synthelabo
Patent: US6800761 B1, 2004 ;
Location in patent: Page column 7 ;
