4-(Cbz-氨基)四氢吡喃-4-羧酸合成路线 （共 5 条）
反应条件
1: in water; acetone T=0 - 20°C; 2: With hydrogenchloride in water pH=1;
参考文献
WO2007/110727 A2, ;
Page/Page column 28 ;
反应条件
1: 8-oxa-1,3-diazaspiro[4.5]decane-2,4-dione With water; potassium hydroxide T=100°C; 66 h; 2: benzyl chloroformate in water; acetone T=0 - 20°C; 3: With hydrogenchloride in water pH=1;
参考文献
WO2012/25701 A1, ;
Page/Page column 33 ;
WO 2012/025701 A1
反应条件
sodium chloride; N-ethyl-N,N-diisopropylamine in water; ethyl acetate; acetonitrile
参考文献
US5270317 A1, ;
US 5270317 A
反应条件
1.1: ethanol; water / 18 h / 60 °C 2.1: potassium hydroxide; water / 66 h / 100 °C 2.2: 0 - 20 °C 2.3: pH 1 View Scheme
参考文献
WO2012/25701 A1, ;
WO 2012/025701 A1
反应条件
in acetone T=0 - 20°C; 79 h; Inert atmosphere;
参考文献
Chemical Communications, , vol. 48, # 28 p. 3397 - 3399
