1: 72 percent / pyridine / 4 h / 0 °C 2: 80 percent / H2 / 10percent Pd-C / ethanol / Ambient temperature 3: H2O; propan-2-ol / pig pancreatic lipase, pH 7 buffer (K2HPO4-KH2PO4) View Scheme

<b>Multi-step reaction with 2 steps<br /> </b>1: 70 percent / NaH / tetrahydrofuran / a.) 0 deg C, 2 h, b.) room temperature, 3 h, c.) 40 deg C, 3 h<br />2: 17.20 g / LiAlH₄ / diethyl ether / a.) 0 deg C, 30 min, b.) room temperature, 5.5 h<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: 89 percent / piperidinium acetate / benzene / Heating<br />2: 70 percent / NaH / tetrahydrofuran / a.) 0 deg C, 2 h, b.) room temperature, 3 h, c.) 40 deg C, 3 h<br />3: 17.20 g / LiAlH₄ / diethyl ether / a.) 0 deg C, 30 min, b.) room temperature, 5.5 h<br /> <br /> &nbsp;