water; sodium hydroxide in ethanol 1 h; Reflux;

1: water; sodium hydroxide / ethanol / 1 h / Reflux 2: dichloromethane / 2 h / 20 °C 3: ammonium hydroxide / dichloromethane / 3 h / 0 - 20 °C 4: hydrogenchloride; water / methanol / 2 h / 20 °C View Scheme

Stage #1: <a href="#" onclick="return RXDsubstances(event, this, '8199221', constants.ctx, '0')">1,3-difluoro-4-(methoxymethoxy)benzene</a> <b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3587206', constants.ctx, '0')">sec.-butyllithium</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '1730733', constants.ctx, '0')">hexane</a> <br />T=-78&deg;C;&nbsp;2&nbsp;h;&nbsp;<br />Stage #2: <a href="#" onclick="return RXDsubstances(event, this, '635955', constants.ctx, '0')">[(Cyanocarbonyl)oxy]ethane</a> &nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '1730733', constants.ctx, '0')">hexane</a> <br />T=-40&deg;C;&nbsp;1&nbsp;h;&nbsp;&nbsp;regioselective reaction;&nbsp;<br /> &nbsp;