2-(3-(三氟甲基)苯基)丙二酸二甲酯合成路线 （共 3 条）
反应条件
1,10-phenanthroline; caesium carbonate; copper(l) iodide in 1,4-dioxane 18 h; Inert atmosphereReflux;
参考文献
E. I. DU PONT DE NEMOURS AND COMPANY; ZHANG, Wenming; ANNIS, Gary David
Patent: WO2013/90547 A1, 2013 ;
Location in patent: Page/Page column 39; 40 ;
反应条件
sodium methylate in methanol T=60°C; 1 h;
参考文献
Dannhardt, G; Meindl, W; Schober, B D; Kappe, T
European Journal of Medicinal Chemistry, 1991 , vol. 26, # 6 p. 599 - 604
反应条件
sodium hydride in tetrahydrofuran; paraffin 2 h; Heating;
参考文献
Miyamoto, Kenji; Tsuchiya, Shigeo; Ohta, Hiromichi
Journal of Fluorine Chemistry, 1992 , vol. 59, # 2 p. 225 - 232
