2-碘-34-二甲氧基苯甲醛合成路线 （共 15 条）
反应条件
1: With n-butyllithium; N,N,N'-trimethyl-ethylenediamine in hexane; benzene T=0 - 20°C; 2: With phenyllithium in hexane; anhydrous butyl ether; benzene T=0 - 20°C; 9 h; 3: With tetrahydrofuran; 1,2-di-iodoethane in hexane; anhydrous butyl ether; benzene T=-78 - 20°C; 16 h;
参考文献
Nielsen, Daniel K.; Nielsen, Laura L.; Jones, Spencer B.; Toll, Lawrence; Asplund, Matthew C.; Castle, Steven L.
Journal of Organic Chemistry, 2009 , vol. 74, # 3 p. 1187 - 1199
反应条件
potassium carbonate in acetone 6 h; Heating;
参考文献
Markovich; Tantishaiyakul; Hamada; Miller; Romstedt; Shams; Shin; Fraundorfer; Doyle; Feller
Journal of Medicinal Chemistry, 1992 , vol. 35, # 3 p. 466 - 479
反应条件
1: With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.333333 h; Inert atmosphere; 2: With N-iodo-succinimide in tetrahydrofuran; hexane T=-78 - 20°C; Inert atmosphere; 3: With hydrogenchloride; water in tetrahydrofuran; hexane 2 h;
参考文献
Onozaki, Yu; Kurono, Nobuhito; Senboku, Hisanori; Tokuda, Masao; Orito, Kazuhiko
Journal of Organic Chemistry, 2009 , vol. 74, # 15 p. 5486 - 5495
反应条件
potassium carbonate in N,N-dimethyl-formamide 20 h;
参考文献
Venter, Daniel P.; Langenhoven, Jan H.
South African Journal of Chemistry, 1996 , vol. 49, # 1-2 p. 40 - 46
反应条件
1: 69.3 percent / iodine monochloride; pyridine / dioxane / 0 - 20 °C 2: 72.2 percent / K2CO3 / acetone / 6 h / Heating View Scheme
参考文献
Markovich; Tantishaiyakul; Hamada; Miller; Romstedt; Shams; Shin; Fraundorfer; Doyle; Feller
Journal of Medicinal Chemistry, 1992 , vol. 35, # 3 p. 466 - 479
反应条件
hydrogenchloride; water in tetrahydrofuran T=20°C; 14 h;
参考文献
Mori, Keiji; Ichikawa, Yuki; Kobayashi, Manato; Shibata, Yukihiro; Yamanaka, Masahiro; Akiyama, Takahiko
Journal of the American Chemical Society, 2013 , vol. 135, # 10 p. 3964 - 3970
参考文献
Raiford; Wells
Journal of the American Chemical Society, 1935 , vol. 57, p. 2500,2502
反应条件
iodine; acetic acid; periodic acid; sulfuric acid in water Heating;
参考文献
Hathaway, Bruce A.; White, Kristen L.; McGill, Mark E.
Synthetic Communications, 2007 , vol. 37, # 21 p. 3855 - 3860
反应条件
1.1: n-butyllithium / hexane; diethyl ether / 4 h / 0 - 20 °C / |Inert atmosphere 1.2: 0.5 h / 0 - 20 °C / |Inert atmosphere 2.1: water; hydrogenchloride / tetrahydrofuran / 14 h / 20 °C View Scheme
参考文献
Mori, Keiji; Ichikawa, Yuki; Kobayashi, Manato; Shibata, Yukihiro; Yamanaka, Masahiro; Akiyama, Takahiko
Journal of the American Chemical Society, 2013 , vol. 135, # 10 p. 3964 - 3970
反应条件
sodium hydride; triphenylphosphine; zinc; NiCl2((PPh3)P)2 in toluene T=90 - 95°C; Ullmann-type coupling reaction; 4 h; Product distribution; Further Variations:Reagentsreaction time;
参考文献
Hong; Hoen; Zhang; Lin
Synlett, 2001 , # 10 p. 1527 - 1530
