5-溴-2-(1-甲基乙氧基)苯甲醛合成路线 （共 7 条）
反应条件
potassium carbonate; caesium carbonate in N-methyl-acetamide
参考文献
Kim, Seyoung; Hwang, Wonmi; Lim, In Seon; Kim, Sung Hye; Lee, Sang-gi; Kim, B. Moon
Tetrahedron Letters, 2010 , vol. 51, # 4 p. 709 - 713
反应条件
N-bromosuccinmide in N,N-dimethyl-formamide T=20°C;
参考文献
AKAAL PHARMA PTY LTD; GILL, Gurmit S; GROBELNY, Damian W
Patent: WO2010/43000 A1, 2010 ;
Location in patent: Page/Page column 78-79 ;
WO 2010/043000 A1
反应条件
potassium carbonate in toluene T=50°C; 12 h;
参考文献
Comber, Mark F.; Sargent, Melvyn V.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991 , p. 2783 - 2787
反应条件
1: 1) 80percent m-chloroperoxybenzoic acid, 2) aq. KOH / 1) CCl4, r.t., 5 h, 2) MeOH, 1 min 2: 97 percent / K2CO3 / acetone / Heating View Scheme
参考文献
Comber, Mark F.; Sargent, Melvyn V.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991 , p. 2783 - 2787
反应条件
n-butyllithium; ammonium chloride in tetrahydrofuran
参考文献
Idenix Pharmaceuticals, Inc.
Patent: US2009/202480 A1, 2009 ;
US 20090202480 A1
反应条件
in tetrahydrofuran T=20°C; 24 h;
参考文献
Andrushko, Vasyl; Schwinn, Dominik; Tzschucke, Carl Christoph; Michalek, Florian; Horn, Joachim; Moessner, Christian; Bannwarth, Willi
Helvetica Chimica Acta, 2005 , vol. 88, # 5 p. 936 - 949
反应条件
1.1: 89 percent / P(o-Tol)3; Et3N / Pd(OAc)2 / dimethylformamide / 5 h / 100 °C
2.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / 0 °C
2.2: 72 percent / tetrahydrofuran; hexane / 20 °C
3.1: 92 percent / aq. KOH / dioxane / 24 h / 20 °C
View Scheme
参考文献
Koc, Fikret; Michalek, Florian; Rumi, Luigi; Bannwarth, Willi; Haag, Rainer
Synthesis, 2005 , # 19 art. no. C05305SS, p. 3362 - 3372
