4-溴-2-(环戊基氧基)苯甲醚合成路线 （共 22 条）
反应条件
2: 100 percent / K2CO3 / acetone / 24 h / Heating View Scheme
参考文献
Meyers, A. I.; Snyder, Lawrence
Journal of Organic Chemistry, 1993 , vol. 58, # 1 p. 36 - 42
反应条件
1: 1.) H2SO4, NaNO2, 2.) Cu2Br2, HBr / 1.) MeOH, H2O, 0 deg C, 45 min, 2.) H2O, reflux, 1.5 h 2: 100 percent / K2CO3 / acetone / 24 h / Heating View Scheme
参考文献
Meyers, A. I.; Snyder, Lawrence
Journal of Organic Chemistry, 1993 , vol. 58, # 1 p. 36 - 42
反应条件
1: NBS / 36 h / 20 °C 2: 85 percent / NaOH (3N) 3: 90 percent / K2CO3 / dimethylformamide / 100 °C View Scheme
参考文献
Conde, Jose J.; Mendelson, Wilford
Tetrahedron Letters, 2000 , vol. 41, # 6 p. 811 - 814
反应条件
1: 70 percent / Br2, AcOH / 48 h / Ambient temperature 2: 87 percent / K2CO3 / dimethylformamide / 24 h / 60 °C View Scheme
参考文献
Diaz, Adolfo; Siro, Jorge G.; Garcia-Navio, Jose L.; Vaquero, Juan J.; Alvarez-Builla, Julio
Synthesis, 1997 , # 5 p. 559 - 562
反应条件
1.1: n-BuLi / diethyl ether; hexane / 1 h / -78 °C 1.2: diethyl ether; hexane / 1 h / -78 °C 2.1: 88 percent / Na2CO3; O2 / Pd(OAc)2 / dimethylformamide / 12 h / 50 °C / 760 Torr 3.1: 90 percent / NBS; AIBN / CCl4 / 10 h / Heating 4.1: 99 percent / NaN3 / ethanol; H2O / 8 h / Heating 5.1: NaBH4; [4(S)-Ph-oxazolidin-2-ylidene][4(S)-Ph-2-oxazolin-2-yl](CN)C / CoCl2*6H2O / ethanol; dimethylformamide / 24 h / 25 °C View Scheme
参考文献
Paraskar, Abhimanyu S.; Sudalai, Arumugam
Tetrahedron, 2006 , vol. 62, # 20 p. 4907 - 4916
反应条件
1.1: tBuLi / tetrahydrofuran 1.2: ZnBr2 / tetrahydrofuran 1.3: 71 percent / Pd2(dibenzylideneacetone)3; 2-dicyclohexylphosphino-2'',6''-diisopropoxy-1,1''-biphenyl / N,N-dimethyl-acetamide 2.1: 95 percent / trifluoroacetic acid / CH2Cl2 / 0.5 h / 20 °C 3.1: 93 percent / H2 / Pd/C View Scheme
参考文献
Albrecht, Dominik; Bach, Thorsten
Synlett, 2007 , # 10 p. 1557 - 1560
反应条件
n-butyllithium; chloro-trimethyl-silane; copper(I) bromide dimethylsulfide complex 1.) Et2O, hexane, THF, -78 deg C, 1 h, 2.) THF, Et2O, hexane, -78 deg C, 1.5 h; Yield given. Multistep reaction;
参考文献
Diaz, Adolfo; Siro, Jorge G.; Garcia-Navio, Jose L.; Vaquero, Juan J.; Alvarez-Builla, Julio
Synthesis, 1997 , # 5 p. 559 - 562
反应条件
n-butyllithium in tetrahydrofuran
参考文献
Merck and Co., Inc.
Patent: US6034089 A1, 2000 ;
US 6034089 A
反应条件
1: With n-butyllithium in tetrahydrofuran; hexane T=-78°C; Metallation; 5 h; 2: With tri-isopropoxy-borane in tetrahydrofuran; hexane T=-78 - 20°C; Substitution; 3: With acetic acid in tetrahydrofuran; hexane; water Hydrolysis;
参考文献
Han, Yongxin; Giroux, Andre; Lepine, Carole; Laliberte, France; Huang, Zheng; Perrier, Helene; Bayly, Christopher I.; Young, Robert N.
Tetrahedron, 1999 , vol. 55, # 39 p. 11669 - 11685
反应条件
hydrogenchloride in tetrahydrofuran; hexane; ethyl acetate
参考文献
American Home Products Corporation
Patent: US5691376 A1, 1997 ;
