1: With sodium hydroxide in methanol; water T=30°C; 0.75 h; 2: With acetic acid in water pH=7;

6-aza-5β,6β-epoxy-cholestane-based tetrafluoroborate salt in dichloromethane T=-70 - 20°C; 3 h;

1: 2,2,2-trifluoroethanol With potassium carbonate in N,N-dimethyl-formamide T=50 - 55°C; Large scale reaction; 2: (R)-(+)-2-(3-methyl-4-nitropyridin-2-ylmethansulfinyl)-1H-benzimidazole in N,N-dimethyl-formamide T=25 - 95°C; Large scale reaction;

1: 3-methyl-4-(2,2,2-trifluoroethoxy)-2-chloromethylpyridine hydrochloride; 2-mercaptobenzoimidazole With sodium hydroxide in water T=25 - 35°C; Inert atmosphere; 2: 2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-pyridin-2-yl]methyl]thio]-1H-benzimidazole With water; (+)-Weinsaeure-diethylester in dichloromethane T=55 - 60°C; 0.25 h; Inert atmosphere;

1: With (R)-2,2'-dihydroxy-1,1'-binaphthyl in dichloromethane T=20 - 40°C; 2: With ammonia in methanol; methyl tert-butyl ether (MTBE) T=25 - 35°C;

(DHQD)2Pyr; dihydrogen peroxide; WO3 in tetrahydrofuran T=0°C; 50 h; Title compound not separated from byproducts;

1.1: titanium(IV) isopropylate; diethyl (2R,3R)-tartrate; water / toluene / 65 - 70 °C / Inert atmosphere 1.2: 0 - 5 °C / Inert atmosphere 2.1: potassium carbonate / N,N-dimethyl-formamide / 50 - 55 °C / Large scale reaction 2.2: 25 - 95 °C / Large scale reaction View Scheme

amylose tris[(S)-1-phenylethylcarbamate] coated APS-Nucleosil in ethanol; hexane Resolution of racemate;