1: 1-bromo-4-methylsulfanyl benzene With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 2 h; 2: acetophenone in tetrahydrofuran; hexane T=-70°C; 10 h; 3: With toluene-4-sulfonic acid in dichloromethane T=20°C; 10 h;

tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran T=40°C; 8 h;

2: 73 percent / Pd(PPh3)4 / tetrahydrofuran / 8 h / 40 °C View Scheme

water in acetone T=25°C; Kinetics;