4-氯-alpha-乙基苄醇合成路线 （共 30 条）
反应条件
1: diethylzinc With 1-((S)-((S)-1-phenylethylamino)(m-tolyl)methyl)naphthalen-2-ol; triethylamine in hexane; toluene
T=20°C; 1 h; Schlenk techniqueInert atmosphere;
2: 4-chlorobenzaldehyde; phenylacetylene in hexane; toluene
T=0 - 20°C; Schlenk techniqueInert atmosphere; Reagent/catalyst; enantioselective reaction;
参考文献
Marinova, Maya; Kostova, Kalina; Tzvetkova, Pavleta; Tavlinova-Kirilova, Maya; Chimov, Angel; Nikolova, Rosica; Shivachev, Boris; Dimitrov, Vladimir
Tetrahedron Asymmetry, 2013 , vol. 24, # 23 p. 1453 - 1466
反应条件
1: diethylzinc With 1-((S)-((S)-1-phenylethylamino)(m-tolyl)methyl)naphthalen-2-ol; triethylamine in hexane; toluene
T=20°C; 1 h; Schlenk techniqueInert atmosphere;
2: cyclopropyl acetylene; 4-chlorobenzaldehyde in hexane; toluene
T=0 - 20°C; Schlenk techniqueInert atmosphere; Reagent/catalyst; enantioselective reaction;
参考文献
Marinova, Maya; Kostova, Kalina; Tzvetkova, Pavleta; Tavlinova-Kirilova, Maya; Chimov, Angel; Nikolova, Rosica; Shivachev, Boris; Dimitrov, Vladimir
Tetrahedron Asymmetry, 2013 , vol. 24, # 23 p. 1453 - 1466
反应条件
1: diethylzinc With 1-((S)-((S)-1-phenylethylamino)(m-tolyl)methyl)naphthalen-2-ol; triethylamine in hexane; toluene
T=20°C; 1 h; Schlenk techniqueInert atmosphere;
2: 1-chloro-4-pentyne; 4-chlorobenzaldehyde in hexane; toluene
T=0 - 20°C; Schlenk techniqueInert atmosphere; enantioselective reaction;
参考文献
Marinova, Maya; Kostova, Kalina; Tzvetkova, Pavleta; Tavlinova-Kirilova, Maya; Chimov, Angel; Nikolova, Rosica; Shivachev, Boris; Dimitrov, Vladimir
Tetrahedron Asymmetry, 2013 , vol. 24, # 23 p. 1453 - 1466
反应条件
in diethyl ether
T=0 - 20°C;
参考文献
Ahern, Theresa; Mueller-Bunz, Helge; Guiry, Patrick J.
Journal of Organic Chemistry, 2006 , vol. 71, # 20 p. 7596 - 7602
反应条件
(R)-2-(1-[(S)-2-(diphenylphosphino)ferrocenylethylimino]methyl)phenol in hexane; toluene
T=0°C; 48 h;
参考文献
Kim, Tae-Jeong; Lee, Hee-Yeol; Ryu, Eun-Sook; Park, Dong-Kyu; Cho, Chan Sik; Shim, Sang Chul; Jeong, Jong Hwa
Journal of Organometalic Chemistry, 2002 , vol. 649, # 2 p. 258 - 267
反应条件
tetra-n-butyl phosphonium chloride in toluene
T=0 - 23°C; Inert atmosphere; chemoselective reaction;
参考文献
Werner, Thomas; Riahi, Abdol Majid; Schramm, Heiko
Synthesis, 2011 , # 21 art. no. N59811SS, p. 3482 - 3490
反应条件
1: ethyl iodide With 1-butylpyridinium bromide; 1-butylpyridinium tetrafluoroborate; zinc
T=50°C; 1 h;
2: 4-chlorobenzaldehyde T=50°C; 12 h;
参考文献
Law, Man Chun; Wong, Kwok-Yin; Chan, Tak Hang
Journal of Organic Chemistry, 2005 , vol. 70, # 25 p. 10434 - 10439
反应条件
isopropyl alcohol; [{RuCl(μ-Cl)(η6-C6Me6)}2]
T=82°C; 24 h;
参考文献
Cadierno, Victorio; Francos, Javier; Gimeno, Jose; Nebra, Noel
Chemical Communications, 2007 , # 24 p. 2536 - 2538
反应条件
1,1'-bis(diphenylphosphino)ferrocene; [Ru2(p-PriC6H4Me)2(μ-Cl)Cl]2; 4-hydroxybutanol; potassium tert-butylate
T=110°C; 48 h; Inert atmosphere;
参考文献
Maytum, Hannah C.; Francos, Javier; Whatrup, David J.; Williams, Jonathan M. J.
Chemistry - An Asian Journal, 2010 , vol. 5, # 3 p. 538 - 542
反应条件
1: 1-bromo-butane With magnesium; ethylene dibromide in 2-methyl tetrahydrofuran
T=20°C; Inert atmosphere;
2: 1-(4-chlorophenyl)-1-propanone in 2-methyl tetrahydrofuran
T=0 - 20°C; Grignard reaction; 1.25 h; Inert atmosphere; chemoselective reaction;
参考文献
Zhong, Weihui; Wu, Yaotiao; Zhang, Xingxian
Journal of Chemical Research, 2009 , # 6 p. 370 - 373
