2-溴-5-甲氧基苯甲腈合成路线 （共 13 条）
反应条件
pyridine; trifluoroacetic anhydride in 1,4-dioxane T=0 - 20°C; 11 h; Inert atmosphere;
参考文献
Malashikhin, Sergey A.; Baldridge, Kim K.; Finney, Nathaniel S.
Organic Letters, 2010 , vol. 12, # 5 p. 940 - 943
反应条件
tert.-butylnitrite; 2-hydroxy-1,3-isoindolinedione; palladium diacetate in acetonitrile T=70°C; 24 h; Inert atmosphereSealed tube;
参考文献
Shu, Zhibin; Ye, Yuxuan; Deng, Yifan; Zhang, Yan; Wang, Jianbo
Angewandte Chemie - International Edition, 2013 , vol. 52, # 40 p. 10573 - 10576
Angew. Chem., 2013 , vol. 125, # 40 p. 10767 - 10770,4
反应条件
[{RuCl2(p-cymene)}2]; acrylic acid methyl ester; diphenyl acetylene in isopropyl alcohol T=100°C; 16 h; Inert atmosphere; regioselective reaction;
参考文献
Chinnagolla, Ravi Kiran; Pimparkar, Sandeep; Jeganmohan, Masilamani
Chemical Communications, 2013 , vol. 49, # 30 p. 3146 - 3148
反应条件
1: dimethylformamide / 8 h / 80 °C 2: 8.7 g / aq. LiOH / tetrahydrofuran / 8 h / 23 °C 3: 96 percent / DMSO; (COCl)2; Et3N / CH2Cl2 / -78 - 20 °C 4: 99 percent / HONH2*HCl; aq. NaOH / ethanol / 12 h / 23 °C 5: 87 percent / 2-chloro-1,3-dimethylimidazolium chloride; Et3N / CH2Cl2 / cooling View Scheme
参考文献
Journal of the American Chemical Society, , vol. 127, # 29 p. 10124 - 10125
反应条件
1: 99 percent / HONH2*HCl; aq. NaOH / ethanol / 12 h / 23 °C 2: 87 percent / 2-chloro-1,3-dimethylimidazolium chloride; Et3N / CH2Cl2 / cooling View Scheme
参考文献
Journal of the American Chemical Society, , vol. 127, # 29 p. 10124 - 10125
反应条件
1: 96 percent / DMSO; (COCl)2; Et3N / CH2Cl2 / -78 - 20 °C 2: 99 percent / HONH2*HCl; aq. NaOH / ethanol / 12 h / 23 °C 3: 87 percent / 2-chloro-1,3-dimethylimidazolium chloride; Et3N / CH2Cl2 / cooling View Scheme
参考文献
Journal of the American Chemical Society, , vol. 127, # 29 p. 10124 - 10125
反应条件
thionyl chloride 3 h; RefluxInert atmosphere;
参考文献
Donaldson, Lauren R.; Wallace, Stephen; Haigh, David; Patton, E. Elizabeth; Hulme, Alison N.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 7 p. 2233 - 2239
反应条件
hydrogenchloride; sodium nitrite Eintragen der bereiteten Diazoniumsalz-Loesung in eine aus Kupfer(I)-cyanid, Natriumcyanid und Wasser hergestellte Loesung und Erwaermen des Reaktionsgemisches;
参考文献
Journal of the American Chemical Society, , vol. 70, p. 2314,2317
反应条件
1: aqueous ethanol; iron; aqueous hydrochloric acid 2: sodium nitrite; aqueous hydrochloric acid / Eintragen der bereiteten Diazoniumsalz-Loesung in eine aus Kupfer(I)-cyanid, Natriumcyanid und Wasser hergestellte Loesung und Erwaermen des Reaktionsgemisches View Scheme
参考文献
Journal of the American Chemical Society, , vol. 70, p. 2314,2317
反应条件
in N,N-dimethyl-formamide T=20°C;
参考文献
Journal of Medicinal Chemistry, , vol. 55, # 7 p. 3135 - 3143
