反应条件
1.1: 64 percent / Pd(PPh3)4 / tetrahydrofuran / 1.5 h / 60 °C
2.1: 99 percent / H2 / Pd/C / 1.5 h / 20 °C / 3102.89 Torr
3.1: 72 percent / m-chloroperbenzoic acid / CH2Cl2 / 2.5 h / 0 - 20 °C
4.1: 99 percent / HCl(gas) / ethyl acetate / 0.25 h / -78 °C
5.1: K2CO3 / toluene; dioxane / 0.5 h / 20 °C
5.2: 85 percent / toluene; dioxane / 4 h / 80 °C
View Scheme
参考文献
Patel, Meena V.; Kolasa, Teodozyj; Mortell, Kathleen; Matulenko, Mark A.; Hakeem, Ahmed A.; Rohde, Jeffrey J.; Nelson, Sherry L.; Cowart, Marlon D.; Nakane, Masaki; Miller, Loan N.; Uchic, Marie E.; Terranova, Marc A.; El-Kouhen, Odile F.; Donnelly-Roberts, Diana L.; Namovic, Marian T.; Hollingsworth, Peter R.; Chang, Renjie; Martino, Brenda R.; Wetter, Jill M.; Marsh, Kennan C.; Martin, Ruth; Darbyshire, John F.; Gintant, Gary; Hsieh, Gin C.; Moreland, Robert B.; Sullivan, James P.; Brioni, Jorge D.; Stewart, Andrew O.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 25 p. 7450 - 7465