N-Boc-3,3-二苯基-L-丙氨酸合成路线 （共 10 条）
反应条件
1: (S)-β,β-diphenyl-α-alanine With sodium hydrogencarbonate in water pH=8 - 9; 2: di-tert-butyl dicarbonate in water; ethyl acetate T=37°C; 16 h; 3: With hydrogenchloride in water; ethyl acetate T=20°C; pH=2;
参考文献
EP1724253 A2, ;
Page/Page column 22 ;
反应条件
sodium hydrogencarbonate in ethanol sonication;
参考文献
Josien, Hubert; Lavielle, Solange; Brunissen, Alie; Saffroy, Monique; Torrens, Yvette; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 11 p. 1586 - 1601
反应条件
1: iPr2NEt / tetrahydrofuran / 1 h / -78 to 0 deg C 2: 1) n-BuLi / 1) THF, -78 deg C, 2) -78 to 0 deg C 3: 1) KHMDS, 2) trisyl azide / 1) THF, -78 deg C, 2) THF, -78 deg C, 2 min 4: LiOH*H2O, 30percent aq. H2O2 / tetrahydrofuran; H2O / 1 h / 0 °C 5: HCl, H2 / 10percent Pd/C / tetrahydrofuran / 20 h / 2585.7 Torr 6: iPr2NEt / methanol View Scheme
参考文献
Tetrahedron Letters, , vol. 33, # 23 p. 3293 - 3296
反应条件
1: 1) n-BuLi / 1) THF, -78 deg C, 2) -78 to 0 deg C 2: 1) KHMDS, 2) trisyl azide / 1) THF, -78 deg C, 2) THF, -78 deg C, 2 min 3: LiOH*H2O, 30percent aq. H2O2 / tetrahydrofuran; H2O / 1 h / 0 °C 4: HCl, H2 / 10percent Pd/C / tetrahydrofuran / 20 h / 2585.7 Torr 5: iPr2NEt / methanol View Scheme
参考文献
Tetrahedron Letters, , vol. 33, # 23 p. 3293 - 3296
反应条件
1: HCl, H2 / 10percent Pd/C / tetrahydrofuran / 20 h / 2585.7 Torr 2: iPr2NEt / methanol View Scheme
参考文献
Tetrahedron Letters, , vol. 33, # 23 p. 3293 - 3296
反应条件
1: 1) KHMDS, 2) trisyl azide / 1) THF, -78 deg C, 2) THF, -78 deg C, 2 min 2: LiOH*H2O, 30percent aq. H2O2 / tetrahydrofuran; H2O / 1 h / 0 °C 3: HCl, H2 / 10percent Pd/C / tetrahydrofuran / 20 h / 2585.7 Torr 4: iPr2NEt / methanol View Scheme
参考文献
Tetrahedron Letters, , vol. 33, # 23 p. 3293 - 3296
反应条件
1: LiOH*H2O, 30percent aq. H2O2 / tetrahydrofuran; H2O / 1 h / 0 °C 2: HCl, H2 / 10percent Pd/C / tetrahydrofuran / 20 h / 2585.7 Torr 3: iPr2NEt / methanol View Scheme
参考文献
Tetrahedron Letters, , vol. 33, # 23 p. 3293 - 3296
反应条件
1: 89 percent / SiO2, 0.5 N HCl / CHCl3 / 2 h / 40 °C / sonication 2: 76 percent / LiOH, LiBr, n-Bu4NBr / acetonitrile / 8 h / Ambient temperature 3: 86 percent / NaHCO3 / ethanol / sonication View Scheme
参考文献
Tetrahedron Letters, , vol. 32, # 45 p. 6547 - 6550
反应条件
1: 76 percent / LiOH, LiBr, n-Bu4NBr / acetonitrile / 8 h / Ambient temperature 2: 86 percent / NaHCO3 / ethanol / sonication View Scheme
参考文献
Tetrahedron Letters, , vol. 32, # 45 p. 6547 - 6550
反应条件
1: 68 percent / 1.) n-BuLi / 1.) hexane, HMPA, -78 deg C, 2.) THF, r. t., 5 d 2: 89 percent / SiO2, 0.5 N HCl / CHCl3 / 2 h / 40 °C / sonication 3: 76 percent / LiOH, LiBr, n-Bu4NBr / acetonitrile / 8 h / Ambient temperature 4: 86 percent / NaHCO3 / ethanol / sonication View Scheme
参考文献
Tetrahedron Letters, , vol. 32, # 45 p. 6547 - 6550
