1: 0.42 g 2: 0.1 M potassium phosphate buffer (pH 7.8) / 24 h / Ambient temperature; horse liver esterase 3: iodine monochloride, 6percent aq. HCl / 1 h / 70 °C View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3587189', constants.ctx, '0')">hydrogen</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '11378922', constants.ctx, '0')">palladium on activated charcoal</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1098229', constants.ctx, '0')">methanol</a> <br />&nbsp;Ambient temperature;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: dimethylformamide / 4 h / 100 - 110 &deg;C<br />2: HCl / 24 h / Ambient temperature<br />3: 100 percent / H₂ / 5percent Pd/C / methanol / Ambient temperature<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: HCl / 24 h / Ambient temperature<br />2: 100 percent / H₂ / 5percent Pd/C / methanol / Ambient temperature<br /> <br /> &nbsp;

<b>Multi-step reaction with 5 steps<br /> </b>1: 1.) NaH / 1.) ethyl ether, reflux, 2.) ethyl ether, RT, 6 h<br />2: aq. KOH / ethanol / 24 h / Heating<br />3: dimethylformamide / 4 h / 100 - 110 &deg;C<br />4: HCl / 24 h / Ambient temperature<br />5: 100 percent / H₂ / 5percent Pd/C / methanol / Ambient temperature<br /> <br /> &nbsp;