1: dimethylformamide / 4 h / 100 - 110 °C 2: HCl / 24 h / Ambient temperature 3: 100 percent / H2 / 5percent Pd/C / methanol / Ambient temperature 4: 0.42 g 5: 0.1 M potassium phosphate buffer (pH 7.8) / 24 h / Ambient temperature; horse liver esterase 6: iodine monochloride, 6percent aq. HCl / 1 h / 70 °C View Scheme

<b>Multi-step reaction with 2 steps<br /> </b>1: 1.) NaH / 1.) ethyl ether, reflux, 2.) ethyl ether, RT, 6 h<br />2: aq. KOH / ethanol / 24 h / Heating<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 1.) NaH / 1.) ethyl ether, reflux, 2.) ethyl ether, RT, 6 h<br />2: aq. KOH / ethanol / 24 h / Heating<br /> <br /> &nbsp;