2-乙氧基羰基-5-吲哚羧酸合成路线 （共 7 条）
反应条件
1: oxalyl dichloride With AlCl3, aluminium chloride in dichloromethane 0.5 h; 2: ethyl 1H-indole-2-carboxylate in dichloromethane 2 h;
参考文献
Aventis Pharma Deutschland GmbH
Patent: EP1479677 A1, 2004 ;
Location in patent: Page 51 ;
EP 1479677 A1
反应条件
zinc(II) chloride cyclocondensation; Heating;
参考文献
Khalaf, Abedawn I.; Pitt, Andrew R.; Suckling, Colin J.; Scobie, Martin; Urwin, John; Waigh, Roger D.; Fishleigh, Robert V.; Young, Stephen C.
Journal of Chemical Research, Miniprint, 2000 , # 6 p. 751 - 770
反应条件
1: 89 percent / aq. AcOH / 1 h / 20 °C 2: ZnCl2 / Heating View Scheme
参考文献
Khalaf, Abedawn I.; Pitt, Andrew R.; Suckling, Colin J.; Scobie, Martin; Urwin, John; Waigh, Roger D.; Fishleigh, Robert V.; Young, Stephen C.
Journal of Chemical Research, Miniprint, 2000 , # 6 p. 751 - 770
反应条件
1: PCl / Behandeln des Reaktionsprodukts mit NaN3 in wss. Aceton und Erhitzen in Toluol 2: concentrated aqueous HCl / Erwaermen des Reaktionsprodukts mit aethanol. HCl View Scheme
参考文献
Journal of Organic Chemistry, , vol. 18, p. 345,356
参考文献
Lindwall; Mantell
Journal of Organic Chemistry, 1953 , vol. 18, p. 345,356
反应条件
potassium hydroxide in ethanol Hydrolysis;
参考文献
Khalaf, Abedawn I.; Pitt, Andrew R.; Suckling, Colin J.; Scobie, Martin; Urwin, John; Waigh, Roger D.; Fishleigh, Robert V.; Young, Stephen C.
Journal of Chemical Research, Miniprint, 2000 , # 6 p. 751 - 770
反应条件
1: PCl / Behandeln des Reaktionsprodukts mit NaN3 in wss. Aceton und Erhitzen in Toluol 2: concentrated aqueous HCl / Erwaermen des Reaktionsprodukts mit aethanol. HCl 3: Na2S2O4; methanol. KOH View Scheme
参考文献
Lindwall; Mantell
Journal of Organic Chemistry, 1953 , vol. 18, p. 345,356
