1: 1 h / subtilisin, pH 7 buffer 2: 20 h / kidney acylase I, pH 7 buffer 3: Na2CO3 / tetrahydrofuran; H2O 4: 60 percent / NBS, H2O / dimethylformamide 5: 80 percent / tetrahydrofuran View Scheme

1: 1 h / subtilisin, pH 7 buffer 2: 20 h / kidney acylase I, pH 7 buffer 3: Na2CO3 / tetrahydrofuran; H2O View Scheme

1: 1 h / subtilisin, pH 7 buffer 2: 20 h / kidney acylase I, pH 7 buffer View Scheme

1: 1 h / subtilisin, pH 7 buffer 2: 20 h / kidney acylase I, pH 7 buffer 3: Na2CO3 / tetrahydrofuran; H2O 4: 78 percent / SO2Cl2 5: 92 percent / Bu3SnH, AIBN / toluene View Scheme