2-甲基-3-乙酰基-4-氯喹啉合成路线 （共 7 条）
反应条件
1: 619 mg / diphenyl ether / 1 h / 250 °C 2: 76 percent / thionyl chloride; DMF / 1 h / 80 °C View Scheme
参考文献
Hoeglund, Iisa P. J.; Silver, Satu; Engstroem, Mia T.; Salo, Harri; Tauber, Andrei; Kyyroenen, Hanna-Kaisa; Saarenketo, Pauli; Hoffren, Anna-Marja; Kokko, Kurt; Pohjanoksa, Katariina; Sallinen, Jukka; Savola, Juha-Matti; Wurster, Siegfried; Kallatsa, Oili A.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 21 p. 6351 - 6363
反应条件
1: pyridine / toluene / 2 h / Heating 2: 619 mg / diphenyl ether / 1 h / 250 °C 3: 76 percent / thionyl chloride; DMF / 1 h / 80 °C View Scheme
参考文献
Hoeglund, Iisa P. J.; Silver, Satu; Engstroem, Mia T.; Salo, Harri; Tauber, Andrei; Kyyroenen, Hanna-Kaisa; Saarenketo, Pauli; Hoffren, Anna-Marja; Kokko, Kurt; Pohjanoksa, Katariina; Sallinen, Jukka; Savola, Juha-Matti; Wurster, Siegfried; Kallatsa, Oili A.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 21 p. 6351 - 6363
反应条件
1: pyridine / toluene / 2 h / Heating 2: 619 mg / diphenyl ether / 1 h / 250 °C 3: 76 percent / thionyl chloride; DMF / 1 h / 80 °C View Scheme
参考文献
Hoeglund, Iisa P. J.; Silver, Satu; Engstroem, Mia T.; Salo, Harri; Tauber, Andrei; Kyyroenen, Hanna-Kaisa; Saarenketo, Pauli; Hoffren, Anna-Marja; Kokko, Kurt; Pohjanoksa, Katariina; Sallinen, Jukka; Savola, Juha-Matti; Wurster, Siegfried; Kallatsa, Oili A.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 21 p. 6351 - 6363
反应条件
1: 70 percent / 1,2-dichloro-benzene / 4 h / Heating 2: 87 percent / NaOMe / methanol / 2 h 3: 89 percent / POCl3 / 2 h / Heating View Scheme
参考文献
Anand, Ramesh C.; Sinha, Arun K.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991 , # 10 p. 2339 - 2342
反应条件
1: 87 percent / NaOMe / methanol / 2 h 2: 89 percent / POCl3 / 2 h / Heating View Scheme
参考文献
Anand, Ramesh C.; Sinha, Arun K.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991 , # 10 p. 2339 - 2342
反应条件
1: 70 percent / 1,2-dichloro-benzene / 4 h / Heating 2: 87 percent / NaOMe / methanol / 2 h 3: 89 percent / POCl3 / 2 h / Heating View Scheme
参考文献
Anand, Ramesh C.; Sinha, Arun K.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991 , # 10 p. 2339 - 2342
反应条件
1: 73 percent / N-bromosuccinimide, benzoyl peroxide / CCl4 / 36 h / Heating
2: 42 percent / dimethylformamide / Ambient temperature
3: 48 percent / K2CO3 / dimethylformamide / 30 h
4: 70 percent / HCl / 1 h / Heating
6: 52 percent / 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) / toluene / 14 h / Heating
View Scheme
参考文献
Anand, Ramesh C.; Sinha, Arun K.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991 , # 10 p. 2339 - 2342
