(R)-N-1-Boc-N-4-Cbz-2-哌嗪甲酸合成路线 (共 4 条)
反应条件
1: C5H10N2O2*2C9H14O4S; benzyl chloroformate With sodium hydroxide in 1,4-dioxane T=0 - 5°C; pH=10.5 - 11.0; 1.5 - 1.75 h; 2: With hydrogenchloride; water pH=4.0; 3: di-tert-butyl dicarbonate With hydrogenchloride; sodium hydroxide more than 3 stages;
参考文献
SCHERING CORPORATION
Patent: EP1140904 B1, 2005 ;
Location in patent: Page/Page column 31-32 ;
反应条件
hydrogen; palladium 10 on activated carbon in ethanol; water P=2844.39 Torr; 18 h;
参考文献
EP1140904 B1, ;
Page/Page column 32 ;
反应条件
caesium carbonate in N,N-dimethyl-formamide
T=20°C; 3 h;
参考文献
SCHERING CORPORATION
Patent: WO2006/65828 A2, 2006 ;
Location in patent: Page/Page column 90 ;
WO 2006/065828 A2
反应条件
1: With 4-methyl-morpholine; isobutyl chloroformate in ethylene glycol dimethyl ether
T=0°C; 0.333333 h;
2: With sodium tetrahydroborate in ethylene glycol dimethyl ether; water
T=20°C;
参考文献
ASTRAZENECA AB
Patent: WO2007/37743 A1, 2007 ;
Location in patent: Page/Page column 47 ;
WO 2007/037743 A1