copper(ll) bromide in 1,2-dichloro-ethane 3 h; Inert atmosphereReflux;

1: bromoacetic acid methyl ester With zinc in tetrahydrofuran T=20°C; 0.5 h; Inert atmosphere; 2: methyl 2-methoxy-2-(piperidin-1-yl)acetate With chloro-trimethyl-silane in tetrahydrofuran T=20°C; 1 h; Inert atmosphere;

copper(ll) bromide in 1,2-dichloro-ethane T=85°C; 0.5 h; Inert atmosphere;

indium tribromide in chloroform T=65°C; 18 h; Inert atmosphere;