(2S)-2-[[[(叔丁基)二苯基硅]氧基]甲基]-2,5-二氢-5-氧代-1H-吡咯-1-羧酸叔丁酯合成路线 （共 9 条）
反应条件
dihydrogen peroxide in tetrahydrofuran; acetic acid T=0°C; 0.5 h;
参考文献
Milne, Claire; Powell, Amanda; Jim, John; Al Nakeeb, Majid; Smith, Colin P.; Micklefield, Jason
Journal of the American Chemical Society, 2006 , vol. 128, # 34 p. 11250 - 11259
反应条件
1.1: LDA / tetrahydrofuran / -78 - 0 °C 1.2: 60 percent / tetrahydrofuran / -78 - 20 °C 2.1: 86 percent / aq. H2O2 / tetrahydrofuran; acetic acid / 0.5 h / 0 °C View Scheme
参考文献
Woo; Jones
Tetrahedron Letters, 1991 , vol. 32, # 47 p. 6949 - 6952
反应条件
pyridine; dihydrogen peroxide in dichloromethane -78 to 0 deg C;
参考文献
Woo; Jones
Tetrahedron Letters, 1991 , vol. 32, # 47 p. 6949 - 6952
反应条件
1: 83 percent / DMAP / CH2Cl2 2: 74 percent / i-Pr2NLi / tetrahydrofuran / -78 °C 3: 90 percent / H2O2, pyridine / CH2Cl2 / -78 to 0 deg C View Scheme
参考文献
FORSCHUNGSVERBUND BERLIN E.V.
Patent: US2011/34438 A1, 2011 ;
反应条件
1: 89 percent / imidazole / CH2Cl2 2: 83 percent / DMAP / CH2Cl2 3: 74 percent / i-Pr2NLi / tetrahydrofuran / -78 °C 4: 90 percent / H2O2, pyridine / CH2Cl2 / -78 to 0 deg C View Scheme
参考文献
FORSCHUNGSVERBUND BERLIN E.V.
Patent: US2011/34438 A1, 2011 ;
反应条件
1: 89 percent / imidazole / CH2Cl2 2: 83 percent / DMAP / CH2Cl2 3: 74 percent / i-Pr2NLi / tetrahydrofuran / -78 °C 4: 90 percent / H2O2, pyridine / CH2Cl2 / -78 to 0 deg C View Scheme
参考文献
FORSCHUNGSVERBUND BERLIN E.V.
Patent: US2011/34438 A1, 2011 ;
反应条件
1: SOCl2 2: NaBH4 3: 89 percent / imidazole / CH2Cl2 4: 83 percent / DMAP / CH2Cl2 5: 74 percent / i-Pr2NLi / tetrahydrofuran / -78 °C 6: 90 percent / H2O2, pyridine / CH2Cl2 / -78 to 0 deg C View Scheme
参考文献
FORSCHUNGSVERBUND BERLIN E.V.
Patent: US2011/34438 A1, 2011 ;
反应条件
1.1: ethanol; lithium chloride; sodium tetrahydroborate / tetrahydrofuran 2.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C / Cooling with ice 3.1: 4-(N,N-dimethlyamino)pyridine / acetonitrile / 15 h / 0 - 20 °C 4.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C 4.2: 2 h / -78 °C 5.1: ozone / dichloromethane / -78 °C View Scheme
参考文献
FORSCHUNGSVERBUND BERLIN E.V.
Patent: US2011/34438 A1, 2011 ;
反应条件
1: NaBH4 2: 89 percent / imidazole / CH2Cl2 3: 83 percent / DMAP / CH2Cl2 4: 74 percent / i-Pr2NLi / tetrahydrofuran / -78 °C 5: 90 percent / H2O2, pyridine / CH2Cl2 / -78 to 0 deg C View Scheme
参考文献
Woo; Jones
Tetrahedron Letters, 1991 , vol. 32, # 47 p. 6949 - 6952
