5-氯-1-(4-氟苯基)-1H-吲哚合成路线 （共 10 条）
反应条件
1: With sodium tetrahydroborate in ethanol Heating / reflux; 2: With hydrogenchloride in ethanol; water T=20°C; 1 h;
参考文献
H. Lundbeck A/S
Patent: EP1260511 A1, 2002 ;
Location in patent: Example 4 ;
反应条件
potassium carbonate; ethylenediamine; copper(I) bromide in N,N-dimethyl-formamide T=130 - 135°C;
参考文献
Beilstein Journal of Organic Chemistry, , vol. 7, p. 29 - 33
反应条件
trifluoroacetic acid in dichloromethane 1 h; Heating;
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 6 p. 1092 - 1101
反应条件
1: NaBH4 / ethanol; various solvent(s) / 0.5 h / 45 - 55 °C 2: TFA / CH2Cl2 / 1 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 6 p. 1092 - 1101
反应条件
1: MgCl2*6H2O, N-methyl-2-pyrrolidone (NMP) / 1 h / 150 °C 2: NaBH4 / ethanol; various solvent(s) / 0.5 h / 45 - 55 °C 3: TFA / CH2Cl2 / 1 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 6 p. 1092 - 1101
反应条件
acetic acid; trifluoroacetic acid 0.5 h; Heating;
参考文献
Perregaard; Arnt; Bogeso; Hyttel; Sanchez
Journal of Medicinal Chemistry, 1992 , vol. 35, # 6 p. 1092 - 1101
反应条件
hydrogenchloride in water; acetic acid T=60 - 95°C; 1.5 h; Heating / refluxIndustry scale;
参考文献
H. Lundbeck A/S
Patent: US6335463 B1, 2002 ;
Location in patent: Page column 7 ;
反应条件
1: TFA, AcOH / 0.5 h / Heating 2: 62 percent / K2CO3, KI / various solvent(s) / 16 h / Heating View Scheme
参考文献
Sunil Kumar; Anjaneyulu; Hima Bindu
Beilstein Journal of Organic Chemistry, 2011 , vol. 7, p. 29 - 33
反应条件
1: TFA, AcOH / 0.5 h / Heating 2: H2, AcOH / PtO2 / ethanol / 16 h / 1900 - 2280 Torr 3: 87 percent / K2CO3, KI / various solvent(s) / 16 h / Heating View Scheme
参考文献
Perregaard; Arnt; Bogeso; Hyttel; Sanchez
Journal of Medicinal Chemistry, 1992 , vol. 35, # 6 p. 1092 - 1101
反应条件
1: TFA, AcOH / 0.5 h / Heating 2: H2, AcOH / PtO2 / ethanol / 16 h / 1900 - 2280 Torr View Scheme
参考文献
Perregaard; Arnt; Bogeso; Hyttel; Sanchez
Journal of Medicinal Chemistry, 1992 , vol. 35, # 6 p. 1092 - 1101
