3-氨基-1-苯基-1H-吡唑-4-甲腈合成路线 （共 6 条）
反应条件
pyridine; copper diacetate in dichloromethane
T=20°C;
参考文献
MERCK andamp; CO., INC.; ALTMAN, Michael; WILSON, Kevin
Patent: WO2010/14453 A1, 2010 ;
Location in patent: Page/Page column 38-39 ;
WO 2010/014453 A1
反应条件
1: With sulfuric acid; water
T=50°C; 3 h;
2: With sodium hydroxide in water
参考文献
MERCK andamp; CO., INC.; ALTMAN, Michael; WILSON, Kevin
Patent: WO2010/14453 A1, 2010 ;
Location in patent: Page/Page column 34 ;
WO 2010/014453 A1
反应条件
hydrogenchloride; water in 1,4-dioxane
72 h; Reflux;
参考文献
MERCK andamp; CO., INC.; ALTMAN, Michael; WILSON, Kevin
Patent: WO2010/14453 A1, 2010 ;
Location in patent: Page/Page column 33-34 ;
WO 2010/014453 A1
反应条件
hydrogenchloride in water
3 h; Heating;
参考文献
Quinn, Ronald J.; Scammells, Peter J.; Kennard, Colin H.L.; Smith, Graham
Australian Journal of Chemistry, 1991 , vol. 44, # 12 p. 1795 - 1801
反应条件
1: 49 percent / POCl3 / 12 h / 100 °C
2: 92 percent / HCl / H2O / 3 h / Heating
View Scheme
参考文献
Quinn, Ronald J.; Scammells, Peter J.; Kennard, Colin H.L.; Smith, Graham
Australian Journal of Chemistry, 1991 , vol. 44, # 12 p. 1795 - 1801
反应条件
in ethanol
2 h; Heating;
参考文献
Gaikwad, Nitin D.; Patil, Sachin V.; Bobade, Vivek D.
Journal of Heterocyclic Chemistry, 2013 , vol. 50, # 3 p. 519 - 527
