1: DEPC, Et3N / dimethylformamide / a) 0 deg C, 2 h, b) r.t. 2: 4N HCl / dioxane / 2 h / Ambient temperature 3: DEPC, Et3N / dimethylformamide / a) 0 deg C, 2 h, b) r.t. 4: 4N HCl / dioxane / 2 h / Ambient temperature 5: 97 percent / DEPC, Et3N / dimethylformamide / a) 0 deg C, 2 h, b) r.t. 6: 1) H2O, LiOH, 2) H2, Pd-black / 1) THF, r.t., 4 h, 2) AcOH, H2O, MeOH, r.t., 1 atm, 11 h View Scheme

1: DEPC, Et3N / dimethylformamide / a) 0 deg C, 2 h, b) r.t. 2: 4N HCl / dioxane / 2 h / Ambient temperature 3: DEPC, Et3N / dimethylformamide / a) 0 deg C, 2 h, b) r.t. 4: 4N HCl / dioxane / 2 h / Ambient temperature 5: DEPC, Et3N / dimethylformamide / a) 0 deg C, 2 h, b) r.t. 6: 4N HCl / dioxane / 2 h / Ambient temperature 7: 97 percent / DEPC, Et3N / dimethylformamide / a) 0 deg C, 2 h, b) r.t. 8: 1) H2O, LiOH, 2) H2, Pd-black / 1) THF, r.t., 4 h, 2) AcOH, H2O, MeOH, r.t., 1 atm, 11 h View Scheme

1: 4N HCl / dioxane / 2 h / Ambient temperature 2: DEPC, Et3N / dimethylformamide / a) 0 deg C, 2 h, b) r.t. 3: 4N HCl / dioxane / 2 h / Ambient temperature 4: DEPC, Et3N / dimethylformamide / a) 0 deg C, 2 h, b) r.t. 5: 4N HCl / dioxane / 2 h / Ambient temperature 6: 97 percent / DEPC, Et3N / dimethylformamide / a) 0 deg C, 2 h, b) r.t. 7: 1) H2O, LiOH, 2) H2, Pd-black / 1) THF, r.t., 4 h, 2) AcOH, H2O, MeOH, r.t., 1 atm, 11 h View Scheme