1: PCl5 2: aqueous NaOH View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '11342937', constants.ctx, '0')">potassium hydroxide</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1098229', constants.ctx, '0')">methanol</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '3587155', constants.ctx, '0')">water</a> <br /> <br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1.1: sodium nitrite; propionic acid / water / 1 h / -5 &deg;C<br />1.2: 16 h / -5 - 20 &deg;C<br />2.1: hydrogen / palladium 10 on activated carbon / ethyl acetate; ethanol / 3.5 h / 20 &deg;C<br />3.1: ethanol / 18 h / Reflux<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: hydrogen / palladium 10 on activated carbon / ethyl acetate; ethanol / 3.5 h / 20 &deg;C<br />2: ethanol / 18 h / Reflux<br /> <br /> &nbsp;