[1-乙酰氧基-5-[[(2S,3S,4S,6R)-3-羟基-2-甲基-6-[[(1S,3S)-3,5,12-三羟基-3-(2-羟基乙酰基)-10-甲氧基-6,11-二氧代-2,4-二氢-1H-并四苯-1-基]氧基]四氢吡喃-4-基]氨基]戊基]乙酸酯合成路线 （共 4 条）
反应条件
sodium cyanoborohydride in tetrahydrofuran; water; acetonitrile 1 h; Ambient temperature;
参考文献
Cherif, Abdallah; Farquhar, David
Journal of Medicinal Chemistry, 1992 , vol. 35, # 17 p. 3208 - 3214
反应条件
1: 59 percent / N-methylmorpholine N-oxide, tetrapropylammonium perruthenate, 4 Angstroem sieves / CH2Cl2 / 2 h / Ambient temperature 2: 94 percent / BF3*Et2O / diethyl ether / 0.17 h / Ambient temperature 3: 1.) O3, 2.) Me2S / 1.) CH2Cl2, -70 deg C, 20 min, 2.) CH2Cl2, overnight 4: NaBH3CN / acetonitrile; H2O; tetrahydrofuran / 1 h / Ambient temperature View Scheme
参考文献
Cherif, Abdallah; Farquhar, David
Journal of Medicinal Chemistry, 1992 , vol. 35, # 17 p. 3208 - 3214
反应条件
1: 94 percent / BF3*Et2O / diethyl ether / 0.17 h / Ambient temperature 2: 1.) O3, 2.) Me2S / 1.) CH2Cl2, -70 deg C, 20 min, 2.) CH2Cl2, overnight 3: NaBH3CN / acetonitrile; H2O; tetrahydrofuran / 1 h / Ambient temperature View Scheme
参考文献
Cherif, Abdallah; Farquhar, David
Journal of Medicinal Chemistry, 1992 , vol. 35, # 17 p. 3208 - 3214
反应条件
1: 1.) O3, 2.) Me2S / 1.) CH2Cl2, -70 deg C, 20 min, 2.) CH2Cl2, overnight 2: NaBH3CN / acetonitrile; H2O; tetrahydrofuran / 1 h / Ambient temperature View Scheme
参考文献
Cherif, Abdallah; Farquhar, David
Journal of Medicinal Chemistry, 1992 , vol. 35, # 17 p. 3208 - 3214
