1: in tetrahydrofuran T=0 - 20°C; 2: With 4-Acetylaminobenzenesulfonyl Azide; 1,8-diazabicyclo[5.4.0]undec-7-ene in tetrahydrofuran T=20°C; 3: With lithium hydroxide in tetrahydrofuran; water

1: 99 percent / Na2CO3, NaI / dimethylformamide / 6 h / 20 - 65 °C 2: 83 percent / tetrahydrofuran / 12 h / Ambient temperature 3: methanesulfonyl azide, Et3N / acetonitrile 4: aq. LiOH / acetonitrile / 20 h / Ambient temperature View Scheme

1: 83 percent / tetrahydrofuran / 12 h / Ambient temperature 2: methanesulfonyl azide, Et3N / acetonitrile 3: aq. LiOH / acetonitrile / 20 h / Ambient temperature View Scheme

1: methanesulfonyl azide, Et3N / acetonitrile 2: aq. LiOH / acetonitrile / 20 h / Ambient temperature View Scheme