S-2-boc-氨基甲基-哌啶合成路线 （共 10 条）
反应条件
1: 87 percent / aq. NaOH / CH2Cl2 / 3 h / 20 °C 2: 68 percent / NaH / tetrahydrofuran / 3 h / 20 °C 3: HCl / methanol / 0.5 h / 20 °C 4: 95 percent / LiAlH4 / diethyl ether / 2 h / 20 °C View Scheme
参考文献
Froelich, Olivier; Cossart, Francoise; Bonin, Martine; Quirion, Jean-Charles; Husson, Henri-Philippe
Heterocycles, 1999 , vol. 51, # 9 p. 2065 - 2072
反应条件
1: 87 percent / aq. NaOH / CH2Cl2 / 3 h / 20 °C 2: 68 percent / NaH / tetrahydrofuran / 3 h / 20 °C 3: HCl / methanol / 0.5 h / 20 °C View Scheme
参考文献
Froelich, Olivier; Cossart, Francoise; Bonin, Martine; Quirion, Jean-Charles; Husson, Henri-Philippe
Heterocycles, 1999 , vol. 51, # 9 p. 2065 - 2072
反应条件
1: With hydrogen; acetic acid; palladium 10 on activated carbon in tetrahydrofuran
T=40°C; P=900.09 - 975.098 Torr; 21 h;
2: With sodium hydroxide in water
pH=> 10;
参考文献
GLAXO GROUP LIMITED
Patent: WO2009/34133 A1, 2009 ;
Location in patent: Page/Page column 14-15 ;
WO 2009/034133 A1
反应条件
1: tetrahydrofuran
2: H2 / 10percent Pd-C / methanol
View Scheme
参考文献
Perumattam, John; Shearer, Barry G.; Confer, William L.; Mathew, Rose M.
Tetrahedron Letters, 1991 , vol. 32, # 49 p. 7183 - 7186
反应条件
1: 75 percent / conc. aq. NH3
2: 80 percent / NEt3 / CH2Cl2
3: 92 percent / LiAlH4 / tetrahydrofuran
4: tetrahydrofuran
5: H2 / 10percent Pd-C / methanol
View Scheme
参考文献
Perumattam, John; Shearer, Barry G.; Confer, William L.; Mathew, Rose M.
Tetrahedron Letters, 1991 , vol. 32, # 49 p. 7183 - 7186
反应条件
1: 80 percent / NEt3 / CH2Cl2
2: 92 percent / LiAlH4 / tetrahydrofuran
3: tetrahydrofuran
4: H2 / 10percent Pd-C / methanol
View Scheme
参考文献
Perumattam, John; Shearer, Barry G.; Confer, William L.; Mathew, Rose M.
Tetrahedron Letters, 1991 , vol. 32, # 49 p. 7183 - 7186
反应条件
1: tetrahydrofuran
2: H2 / 10percent Pd-C / methanol
View Scheme
参考文献
Perumattam, John; Shearer, Barry G.; Confer, William L.; Mathew, Rose M.
Tetrahedron Letters, 1991 , vol. 32, # 49 p. 7183 - 7186
反应条件
1: 92 percent / LiAlH4 / tetrahydrofuran
2: tetrahydrofuran
3: H2 / 10percent Pd-C / methanol
View Scheme
参考文献
Perumattam, John; Shearer, Barry G.; Confer, William L.; Mathew, Rose M.
Tetrahedron Letters, 1991 , vol. 32, # 49 p. 7183 - 7186
反应条件
1: 81 percent / HCl
2: 75 percent / conc. aq. NH3
3: 80 percent / NEt3 / CH2Cl2
4: 92 percent / LiAlH4 / tetrahydrofuran
5: tetrahydrofuran
6: H2 / 10percent Pd-C / methanol
View Scheme
参考文献
Perumattam, John; Shearer, Barry G.; Confer, William L.; Mathew, Rose M.
Tetrahedron Letters, 1991 , vol. 32, # 49 p. 7183 - 7186
反应条件
1: 96 percent / dioxane; H2O / 0.25 h / 20 °C
2: 84 percent / hydrogen / Pd/C / methanol / 4 h
View Scheme
参考文献
Froelich, Olivier; Cossart, Francoise; Bonin, Martine; Quirion, Jean-Charles; Husson, Henri-Philippe
Heterocycles, 1999 , vol. 51, # 9 p. 2065 - 2072
