8-氟咪唑并[1,2-a]吡啶合成路线 (共 4 条)
反应条件
1: With hydrogen bromide in water T=90°C; 0.333333 h; 2: With sodium hydrogencarbonate in water; isopropyl alcohol T=50°C; 18 h;
参考文献
WO2003/99816 A1, ;
Page 43-44 ;
WO 03/099816 A1
反应条件
1: aq. HBr / 90 °C 2: ethanol / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 6 p. 1518 - 1522
反应条件
1: Cs2CO3; BINAP; Pd(OAc)2 / toluene / 95 °C 2: aq. HBr / 90 °C 3: ethanol / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 6 p. 1518 - 1522
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 6 p. 1518 - 1522