(1-苄基哌啶-4-基)(甲基)氨基甲酸叔丁酯合成路线 （共 6 条）
反应条件
in tetrahydrofuran; water T=20°C; Acylation; 2 h;
参考文献
GRUENENTHAL GmbH
Patent: US2012/71461 A1, 2012 ;
Location in patent: Page/Page column 144 ;
反应条件
1: 1-Phenylmethyl-piperidin-4-one; methylamine With sodium tris(acetoxy)borohydride in tetrahydrofuran T=20°C; 2: With methanol in tetrahydrofuran T=70°C; 1.5 h; 3: di-tert-butyl dicarbonate in dichloromethane
参考文献
sanofi-aventis
Patent: US2008/269170 A1, 2008 ;
Location in patent: Page/Page column 21 ;
反应条件
sodium hydroxide in tetrahydrofuran; water
参考文献
Merck Sharp and Dohme, Ltd.
Patent: US5854268 A1, 1998 ;
反应条件
1: 99 percent / CH2Cl2 / 18 h / 20 °C 2: LiAlH4 / tetrahydrofuran / 2.5 h / Heating 3: tetrahydrofuran; H2O / 2 h / 20 °C View Scheme
参考文献
Russell, Michael G. N.; Matassa, Victor G.; Pengilley, Roy R.; Van Niel, Monique B.; Sohal, Bindi; Watt, Alan P.; Hitzel, Laure; Beer, Margaret S.; Stanton, Josephine A.; Broughton, Howard B.; Castro, Jose L.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 24 p. 4981 - 5001
反应条件
1: LiAlH4 / tetrahydrofuran / 2.5 h / Heating 2: tetrahydrofuran; H2O / 2 h / 20 °C View Scheme
参考文献
Russell, Michael G. N.; Matassa, Victor G.; Pengilley, Roy R.; Van Niel, Monique B.; Sohal, Bindi; Watt, Alan P.; Hitzel, Laure; Beer, Margaret S.; Stanton, Josephine A.; Broughton, Howard B.; Castro, Jose L.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 24 p. 4981 - 5001
反应条件
1.1: acetic acid / methanol / 2 h / 20 °C 1.2: 16 h / 0 - 20 °C 2.1: triethylamine / dichloromethane / 16 h / 0 - 20 °C View Scheme
参考文献
GRUENENTHAL GmbH
Patent: US2012/71461 A1, 2012 ;
