1: tetrahydrofuran 2: NaOH / dioxane 3: HOBt, EDI / dimethylformamide View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3587189', constants.ctx, '0')">hydrogen</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '11378922', constants.ctx, '0')">palladium on activated charcoal</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1718733', constants.ctx, '0')">ethanol</a> <br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: 10N NaOH, Na₂CO₃ / H₂O; tetrahydrofuran / Ambient temperature<br />2: KHCO₃ / dimethylformamide / 12 h<br />3: 90 percent / TFA / CH₂Cl₂ / 3 h / Ambient temperature<br /> <br /> &nbsp;

<b>Multi-step reaction with 6 steps<br /> </b>1: diisobutylaluminium hydride / toluene; hexane / -77 &deg;C<br />2: sodium metabisulfite / H₂O / 5 h / Ambient temperature<br />3: 25percent aq. HCl / 12 h / 80 &deg;C<br />4: 10N NaOH, Na₂CO₃ / H₂O; tetrahydrofuran / Ambient temperature<br />5: KHCO₃ / dimethylformamide / 12 h<br />6: 90 percent / TFA / CH₂Cl₂ / 3 h / Ambient temperature<br /> <br /> &nbsp;

<b>Multi-step reaction with 5 steps<br /> </b>1: sodium metabisulfite / H₂O / 5 h / Ambient temperature<br />2: 25percent aq. HCl / 12 h / 80 &deg;C<br />3: 10N NaOH, Na₂CO₃ / H₂O; tetrahydrofuran / Ambient temperature<br />4: KHCO₃ / dimethylformamide / 12 h<br />5: 90 percent / TFA / CH₂Cl₂ / 3 h / Ambient temperature<br /> <br /> &nbsp;

<b>Multi-step reaction with 7 steps<br /> </b>1: NaHCO₃ / H₂O; tetrahydrofuran / Ambient temperature<br />2: diisobutylaluminium hydride / toluene; hexane / -77 &deg;C<br />3: sodium metabisulfite / H₂O / 5 h / Ambient temperature<br />4: 25percent aq. HCl / 12 h / 80 &deg;C<br />5: 10N NaOH, Na₂CO₃ / H₂O; tetrahydrofuran / Ambient temperature<br />6: KHCO₃ / dimethylformamide / 12 h<br />7: 90 percent / TFA / CH₂Cl₂ / 3 h / Ambient temperature<br /> <br /> &nbsp;