2′,3′,4′-三甲氧基苯乙酮合成路线 （共 43 条）
反应条件
1: AcOOH, HClO4, Ac2O 2: KOH / ethanol / Heating 3: K2CO3 / acetone; benzene 4: AlCl3 / CS2 / Heating View Scheme
参考文献
Zaninetti, Roberta; Cortese, Salvatore V.; Aprile, Silvio; Massarotti, Alberto; Canonico, Pier Luigi; Sorba, Giovanni; Grosa, Giorgio; Genazzani, Armando A.; Pirali, Tracey
ChemMedChem, 2013 , vol. 8, # 4 p. 633 - 643
反应条件
potassium hydroxide; dihydrogen peroxide; trifluoroacetic anhydride 1.) CH2Cl2, -40 deg C, 20 min, 2.) MeOH, reflux, 30 min; Yield given. Multistep reaction;
参考文献
Huee,R. et al.
Bulletin de la Societe Chimique de France, 1970 , p. 3617 - 3624
反应条件
AlCl3, aluminium chloride in dichloromethane T=-5 - 25°C;
参考文献
Du, Zhen-Ting; Lu, Jing; Yu, Hong-Rui; Xu, Yan; Li, An-Pai
Journal of Chemical Research, 2010 , # 4 p. 222 - 227
参考文献
Okazaki
Yakugaku Zasshi, 1939 , vol. 59, p. 547,549; dtsch. Ref. S. 190, 192
Chem.Abstr., 1940 , p. 1004
参考文献
Ahluwalia et al.
Proceedings - Indian Academy of Sciences, Section A, 1958 , # 47 p. 230,232
反应条件
1: 1.) 75percent H2O2,trifluoroacetic anhydride, 2.) KOH / 1.) CH2Cl2, -40 deg C, 20 min, 2.) MeOH, reflux, 30 min 2: 97 percent / K2CO3 / acetone / 22 h / Heating 3: 92 percent / Br2 / CH2Cl2 / -10 °C 4: 1.) n-BuLi / 1.) Et2O, 30 min, 2.) Et2O, 1 h, low temperature, 10 h, room temperature, 3 h, reflux 5: 83 percent / Br2 / CH2Cl2 / 3 - 5 °C View Scheme
参考文献
Tetrahedron, , vol. 36, # 1 p. 123 - 129
反应条件
1: AcOOH, HClO4, Ac2O 2: KOH / ethanol / Heating 3: K2CO3 / acetone; benzene 4: POCl3 5: AcOOH, HClO4, Ac2O / acetic acid View Scheme
参考文献
Huee,R. et al.
Bulletin de la Societe Chimique de France, 1970 , p. 3617 - 3624
反应条件
1: sodium / 120 °C 2: aqueous hydriodic acid; acetic acid anhydride / 140 °C View Scheme
参考文献
Badhwar; Kang; Venkataraman
Journal of the Chemical Society, 1932 , p. 1107,1108
反应条件
1: 1.) 75percent H2O2,trifluoroacetic anhydride, 2.) KOH / 1.) CH2Cl2, -40 deg C, 20 min, 2.) MeOH, reflux, 30 min 2: 97 percent / K2CO3 / acetone / 22 h / Heating View Scheme
参考文献
Huee,R. et al.
Bulletin de la Societe Chimique de France, 1970 , p. 3617 - 3624
反应条件
sodium methylate; thallium(III) nitrate 1.) methylene chloride, 0 to room temperatue; 2.) methanol, H2O, overnight; Yield given. Multistep reaction;
参考文献
Lenz; Woo
Journal of Heterocyclic Chemistry, 1981 , vol. 18, # 4 p. 691 - 693
