2-[2-(2-T-BOC-氨基乙氧基)乙氧基]乙醇合成路线 （共 14 条）
反应条件
potassium hydroxide in 1,4-dioxane; water 1) 0 deg C, 1 h, 2) room temp., 4 h;
参考文献
Lebeau, Luc; Oudet, Pierre; Mioskowski, Charles
Helvetica Chimica Acta, 1991 , vol. 74, # 8 p. 1697 - 1706
反应条件
1: 100 percent / triphenylphosphine, H2O / tetrahydrofuran / 4 h / Ambient temperature 2: 93 percent / KOH / H2O; dioxane / 1) 0 deg C, 1 h, 2) room temp., 4 h View Scheme
参考文献
Moreau, Julie; Marchand-Brynaert, Jacqueline
European Journal of Organic Chemistry, 2011 , # 9 p. 1641 - 1644
反应条件
1: 45 percent / Et3N / tetrahydrofuran / 1) -5 deg C, 2 h, 2) room temp., overnight 2: 88 percent / NaN3 / acetonitrile / 36 h / Heating 3: 100 percent / triphenylphosphine, H2O / tetrahydrofuran / 4 h / Ambient temperature 4: 93 percent / KOH / H2O; dioxane / 1) 0 deg C, 1 h, 2) room temp., 4 h View Scheme
参考文献
Moreau, Julie; Marchand-Brynaert, Jacqueline
European Journal of Organic Chemistry, 2011 , # 9 p. 1641 - 1644
反应条件
Pearlman's catalist; hydrogen in methanol P=3102.97 Torr; 4 h;
参考文献
Shukla, Nikunj M.; Malladi, Subbalakshmi S.; Mutz, Cole A.; Balakrishna, Rajalakshmi; David, Sunil A.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 11 p. 4450 - 4465
反应条件
1: sodium azide / N,N-dimethyl-formamide / 20 °C 2: palladium on carbon; hydrogen / tetrahydrofuran 3: dichloromethane View Scheme
参考文献
Hammaecher, Catherine; Joris, Bernard; Goormaghtigh, Erik; Marchand-Brynaert, Jacqueline
European Journal of Organic Chemistry, 2013 , # 35 p. 7952 - 7959
反应条件
1: 88 percent / NaN3 / acetonitrile / 36 h / Heating 2: 100 percent / triphenylphosphine, H2O / tetrahydrofuran / 4 h / Ambient temperature 3: 93 percent / KOH / H2O; dioxane / 1) 0 deg C, 1 h, 2) room temp., 4 h View Scheme
参考文献
Simonin, Jonathan; Vernekar, Sanjeev Kumar V.; Thompson, Andrew J.; Hothersall, J. Daniel; Connolly, Christopher N.; Lummis, Sarah C.R.; Lochner, Martin
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 2 p. 1151 - 1155
反应条件
1: sodium azide; sodium iodide / water / 96 h / 50 °C 2: palladium 10 on activated carbon; hydrogen / ethanol 3: ethanol View Scheme
参考文献
Dakanali, Marianna; Do, Thai H.; Horn, Austin; Chongchivivat, Akaraphon; Jarusreni, Tuptim; Lichlyter, Darcy; Guizzunti, Gianni; Haidekker, Mark A.; Theodorakis, Emmanuel A.
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 14 p. 4443 - 4450
反应条件
5-palladium/activated carbon; hydrogen in methanol
参考文献
Shimokawa, Kenichiro; Yamada, Kaoru; Ohno, Osamu; Oba, Yuichi; Uemura, Daisuke
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 1 p. 92 - 95
反应条件
1.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 1.5 h / Reflux 1.2: 20 °C 2.1: palladium 10 on activated carbon; hydrogen / ethanol / 70 °C / 52505.3 Torr / Continuous-flow conditions 3.1: triethylamine / methanol / 3 h / Reflux View Scheme
参考文献
Howarth, Nicola M.; Ricci, Jennyfer
Tetrahedron, 2011 , vol. 67, # 49 p. 9588 - 9594
反应条件
1: palladium 10 on activated carbon; hydrogen / ethanol / 70 °C / 52505.3 Torr / Continuous-flow conditions 2: triethylamine / methanol / 3 h / Reflux View Scheme
参考文献
Howarth, Nicola M.; Ricci, Jennyfer
Tetrahedron, 2011 , vol. 67, # 49 p. 9588 - 9594
