4-[2-(苯甲酰氧基)乙基]-3-氯-1,3-二氢-2h-吲哚-2-酮合成路线 （共 10 条）
反应条件
anhydrous iron chloride in dichloromethane T=-10 - 0°C;
参考文献
SUGEN, Inc.
Patent: US2004/186160 A1, 2004 ;
Location in patent: Page/Page column 22 ;
US 20040186160 A1
反应条件
1: 100 percent / ZnCl2 / CH2Cl2 / 1 h / Heating 2: 1.) hexamethylenetetramine, 2.) aq. AcOH / 1.) ethanol, reflux, 90 min, 2.) ethanol, reflux 3: 87 percent / AcOH, n-BuNH2 / methanol / 18 h / 22 °C 4: 64 percent / AcCl, FeCl3 / CH2Cl2 / 1 h / 0 - 5 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 32, # 3 p. 875 - 882
反应条件
1: 100 percent / ZnCl2 / CH2Cl2 / 1 h / Heating 2: 1.) hexamethylenetetramine, 2.) aq. AcOH / 1.) ethanol, reflux, 90 min, 2.) ethanol, reflux 3: 87 percent / AcOH, n-BuNH2 / methanol / 18 h / 22 °C 4: 64 percent / AcCl, FeCl3 / CH2Cl2 / 1 h / 0 - 5 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 32, # 3 p. 875 - 882
反应条件
1: 1.) hexamethylenetetramine, 2.) aq. AcOH / 1.) ethanol, reflux, 90 min, 2.) ethanol, reflux 2: 87 percent / AcOH, n-BuNH2 / methanol / 18 h / 22 °C 3: 64 percent / AcCl, FeCl3 / CH2Cl2 / 1 h / 0 - 5 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 32, # 3 p. 875 - 882
反应条件
1: 87 percent / AcOH, n-BuNH2 / methanol / 18 h / 22 °C 2: 64 percent / AcCl, FeCl3 / CH2Cl2 / 1 h / 0 - 5 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 32, # 3 p. 875 - 882
反应条件
1: hydrazine hydrate, 10percent Pd-C / methanol; H2O / 0.5 h / Heating 2: aq. NaOH / methanol / 0.5 h / Heating 3: 80 percent / pyridine / CH2Cl2 / 5 - 10 °C 4: H2O / 2 h / Heating View Scheme
参考文献
Hayler; Howie; Giles; Negus; Oxley; Walsgrove; Walsh; Dagger; Fortunak; Mastrocola
Journal of Heterocyclic Chemistry, 1995 , vol. 32, # 3 p. 875 - 882
反应条件
1: palladium on activated charcoal; hydrazine hydrate 2: sodium hydroxide; water / |Large scale 3: pyridine / |Large scale 4: hydrogenchloride / water / |Large scale View Scheme
参考文献
Hayler, John D.; Howie, Simon L. B.; Giles, Robert G.; Negus, Alan; Oxley, Paul W.; Walsgrove, Timothy C.; Whiter
Organic Process Research and Development, 1998 , vol. 2, # 1 p. 3 - 9
反应条件
palladium on activated charcoal; hydrazine hydrate in methanol; water 0.5 h; Heating;
参考文献
Hayler, John D.; Howie, Simon L. B.; Giles, Robert G.; Negus, Alan; Oxley, Paul W.; Walsgrove, Timothy C.; Whiter
Organic Process Research and Development, 1998 , vol. 2, # 1 p. 3 - 9
反应条件
1: hydrazine hydrate, 10percent Pd-C / methanol; H2O / 0.5 h / Heating 2: aq. NaOH / methanol / 0.5 h / Heating 3: 87 percent / pyridine / CH2Cl2 / 4 h / 5 - 10 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 32, # 3 p. 875 - 882
反应条件
1: With hydrazine; 5-palladium/activated carbon in methanol; water 1 h; Heating / reflux; 2: With methanol; sodium hydroxide; water 0.5 h; Heating / reflux;
参考文献
US2004/186160 A1, ;
Page/Page column 22-23 ;
US 20040186160 A1
