2,4-二氟苯磺酰氯合成路线

参考文献

Pal, Manojit; Madan, Manjula; Padakanti, Srinivas; Pattabiraman, Vijaya R.; Kalleda, Srinivas; Vanguri, Akhila; Mullangi, Ramesh; Mamidi, N. V. S. Rao; Casturi, Seshagiri R.; Malde, Alpeshkumar; Gopalakrishnan; Yeleswarapu, Koteswar R.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 19 p. 3975 - 3984

367-25-92,4-二氟苯胺

13918-92-82,4-二氟苯磺酰氯

参考文献

US4600709 A1, ;

3782-65-8

13918-92-82,4-二氟苯磺酰氯

参考文献

J. Gen. Chem. USSR (Engl. Transl.), , vol. 37, # 1 p. 163 - 170,149 - 155

26120-88-7

13918-92-82,4-二氟苯磺酰氯

参考文献

J. Gen. Chem. USSR (Engl. Transl.), , vol. 37, # 1 p. 163 - 170,149 - 155

884495-39-03-氨基-5-溴-2-甲氧基吡啶+

13918-92-82,4-二氟苯磺酰氯

1086063-46-8N-(5-溴-2-甲氧基吡啶-3-基)-2,4-二氟苯磺酰胺

参考文献

GLAXOSMITHKLINE LLC; BOTYANSZKI, Janos; DICKERSON, Scott Howard; LEIVERS, Martin Robert; LI, Xiaofei; MCFADYEN, Robert Blount; REDMAN, Aniko Maria; SHOTWELL, John Bradford; XUE, Jianjun
Patent: WO2012/174312 A2, 2012 ;
Location in patent: Page/Page column 214 ;
WO 2012/174312 A2

1336-21-6氨水+

13918-92-82,4-二氟苯磺酰氯

13656-60-52,4-二氟苯磺酰胺

参考文献

Pharmacia Corporation
Patent: US2002/183362 A1, 2002 ;

13918-92-82,4-二氟苯磺酰氯

13656-60-52,4-二氟苯磺酰胺

参考文献

Pal, Manojit; Madan, Manjula; Padakanti, Srinivas; Pattabiraman, Vijaya R.; Kalleda, Srinivas; Vanguri, Akhila; Mullangi, Ramesh; Mamidi, N. V. S. Rao; Casturi, Seshagiri R.; Malde, Alpeshkumar; Gopalakrishnan; Yeleswarapu, Koteswar R.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 19 p. 3975 - 3984

893440-50-13-氨基-2-甲氧基吡啶-5-硼酸频哪醇酯+

13918-92-82,4-二氟苯磺酰氯

1083326-73-12,4-二氟-n-[2-甲氧基-5-(4,4,5,5-四甲基-1,3,2-二噁硼烷-2-基)-3-吡啶]-苯磺酰胺

参考文献

Su, Weiguo; Zhang, Weihan; Yang, Haibin
Patent: US2013/190307 A1, 2013 ;
Location in patent: Paragraph 0158; 0161 ;

893440-50-13-氨基-2-甲氧基吡啶-5-硼酸频哪醇酯+

13918-92-82,4-二氟苯磺酰氯

1083326-73-12,4-二氟-n-[2-甲氧基-5-(4,4,5,5-四甲基-1,3,2-二噁硼烷-2-基)-3-吡啶]-苯磺酰胺

参考文献

GLAXO GROUP LIMITED; HAMBLIN, Julie, Nicole; JONES, Paul, Spencer; KEELING, Suzanne, Elaine; LE, Joelle; MITCHELL, Charlotte, Jane; PARR, Nigel, James
Patent: WO2010/125082 A1, 2010 ;
Location in patent: Page/Page column 75-76 ;
WO 2010/125082 A1

13918-92-82,4-二氟苯磺酰氯

1083326-73-12,4-二氟-n-[2-甲氧基-5-(4,4,5,5-四甲基-1,3,2-二噁硼烷-2-基)-3-吡啶]-苯磺酰胺

参考文献

Leivers, Anna L.; Tallant, Matthew; Shotwell, J. Brad; Dickerson, Scott; Leivers, Martin R.; McDonald, Octerloney B.; Gobel, Jeff; Creech, Katrina L.; Strum, Susan L.; Mathis, Amanda; Rogers, Sabrinia; Moore, Chris B.; Botyanszki, Janos
Journal of Medicinal Chemistry, 2014 , vol. 57, # 5 p. 2091 - 2106