5-羟基吡嗪-2-羧酸甲酯合成路线 （共 8 条）
反应条件
thionyl chloride 2 h; Heating;
参考文献
Mano; Seo; Iami
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 10 p. 3057 - 3063
反应条件
thionyl chloride 2 h; Heating;
参考文献
Mano; Seo; Iami
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 10 p. 3057 - 3063
反应条件
1: 77 percent / 10percent NaOH / H2O / 3 h / Heating 2: 64 percent / SOCl2 / 2 h / Heating View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 28, # 10 p. 3057 - 3063
反应条件
1: 26 percent / 10percent Na2CO3 / 8 h / Heating 2: 61 percent / nitrobenzene / 3 h / 170 - 180 °C 3: 77 percent / 10percent NaOH / H2O / 3 h / Heating 4: 64 percent / SOCl2 / 2 h / Heating View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 28, # 10 p. 3057 - 3063
反应条件
1: 61 percent / nitrobenzene / 3 h / 170 - 180 °C 2: 77 percent / 10percent NaOH / H2O / 3 h / Heating 3: 64 percent / SOCl2 / 2 h / Heating View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 28, # 10 p. 3057 - 3063
反应条件
1: With trichlorophosphate; N,N-dimethyl-formamide in chloroform 2 h; RefluxInert atmosphere; 2: With sodium hydrogencarbonate in chloroform; water
参考文献
Daiichi Sankyo Company, Limited
Patent: EP2239253 A1, 2010 ;
Location in patent: Page/Page column 96 ;
EP 2239253 A1
反应条件
1: trichlorophosphate / 1.5 h / |Reflux 2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 20 °C View Scheme
参考文献
PFIZER LIMITED; COE, Jotham, Wadsworth; DEHNHARDT, Christoph, Martin; JONES, Peter; KORTUM, Steven Wade; SABNIS, Yogesh, Anil; WAKENHUT, Florian, Michel; WHITLOCK, Gavin, Alistair
Patent: WO2013/14567 A1, 2013 ;
WO 2013/014567 A1
反应条件
1: 68 percent / POCl3, DMF / 2 h / Heating
2: 6 percent / MCPBA / 1,2-dichloro-ethane / 39 h / 65 °C
3: 10 percent / NaOH / H2O / 5 h / 70 - 80 °C
View Scheme
参考文献
Mano; Seo; Iami
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 10 p. 3057 - 3063
