1: With water; potassium carbonate 2 h; Heating / reflux; 2: With hydrogenchloride in water T=20°C; pH=2; 5 h; Heating / reflux; 3: With sodium hydroxide in water pH=10 - 11;

1: With hydrogenchloride in water T=90°C; 1 h; 2: With sodium hydroxide in water pH=7;

1: 99 percent / SOCl2 / Ambient temperature 2: 46 percent / sodium borohydride / ethanol; H2O / 2.5 h / Heating 3: 36 percent / aq. KOH / toluene / 1 h / 0 °C 4: 97 percent / H2, aq. 2 N HCl / 10percent Pd/C / ethanol; ethyl acetate 5: 1.) aq. HCl, NaNO2, 2.) SnCl2 / 1.) from -5 deg C to 0 deg C, 30 min, 2.) RT, 3 h 6: 0.21 g / ethanol; H2O / 2 h / Heating View Scheme

1: 36 percent / aq. KOH / toluene / 1 h / 0 °C 2: 97 percent / H2, aq. 2 N HCl / 10percent Pd/C / ethanol; ethyl acetate 3: 1.) aq. HCl, NaNO2, 2.) SnCl2 / 1.) from -5 deg C to 0 deg C, 30 min, 2.) RT, 3 h 4: 0.21 g / ethanol; H2O / 2 h / Heating View Scheme

1: 46 percent / sodium borohydride / ethanol; H2O / 2.5 h / Heating 2: 36 percent / aq. KOH / toluene / 1 h / 0 °C 3: 97 percent / H2, aq. 2 N HCl / 10percent Pd/C / ethanol; ethyl acetate 4: 1.) aq. HCl, NaNO2, 2.) SnCl2 / 1.) from -5 deg C to 0 deg C, 30 min, 2.) RT, 3 h 5: 0.21 g / ethanol; H2O / 2 h / Heating View Scheme

1: 97 percent / H2, aq. 2 N HCl / 10percent Pd/C / ethanol; ethyl acetate 2: 1.) aq. HCl, NaNO2, 2.) SnCl2 / 1.) from -5 deg C to 0 deg C, 30 min, 2.) RT, 3 h 3: 0.21 g / ethanol; H2O / 2 h / Heating View Scheme

in ethanol; water 2 h; Heating;

暂无反应条件数据

1: With sodium cyanoborohydride; acetic acid in methanol; water T=5 - 20°C; 2 h; 2: With potassium carbonate in methanol; water pH=10 - 11; Product distribution / selectivity;