(S)-4-(4-硝基苄基)-2-噁唑烷酮合成路线 (共 9 条)
反应条件
potassium hydroxide in toluene T=0 - 20°C; 2 h;
参考文献
Moloney, Gerard P.; Robertson, Alan D.; Martin, Graeme R.; MacLennan, Steven; Mathews, Neil; Dodsworth, Susan; Sang, Pang Yih; Knight, Cameron; Glen, Robert
Journal of Medicinal Chemistry, 1997 , vol. 40, # 15 p. 2347 - 2362
反应条件
nitric acid in dichloromethane T=20°C; 2 h;
参考文献
Ahmed, Sabbir; Adat, Shaheen; Murrells, Annabel; Owen, Caroline P.; Amanuel, Yonas
Bioorganic Chemistry, 2002 , vol. 30, # 5 p. 315 - 331
反应条件
1: With potassium carbonate in toluene T=10 - 15°C; 2: With water in toluene T=20 - 25°C; Product distribution / selectivity;
参考文献
WO2008/18090 A2, ;
Page/Page column 8 ;
反应条件
1: 76 percent / SOCl2 / 4 h / -10 - 40 °C 2: 65 percent / NaBH4 / ethanol; H2O / 4 h / Heating 3: 75 percent / 0.2M aq. KOH / toluene / 2 h / 0 - 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 40, # 15 p. 2347 - 2362
反应条件
1: 65 percent / NaBH4 / ethanol; H2O / 4 h / Heating 2: 75 percent / 0.2M aq. KOH / toluene / 2 h / 0 - 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 40, # 15 p. 2347 - 2362
反应条件
1: 53 percent / conc. H2SO4, conc. HNO3 / 0.5 h / Ambient temperature 2: 76 percent / SOCl2 / 4 h / -10 - 40 °C 3: 65 percent / NaBH4 / ethanol; H2O / 4 h / Heating 4: 75 percent / 0.2M aq. KOH / toluene / 2 h / 0 - 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 40, # 15 p. 2347 - 2362
反应条件
1: 97 percent / H2, aq. 2 N HCl / 10percent Pd/C / ethanol; ethyl acetate 2: 1.) aq. HCl, NaNO2, 2.) SnCl2 / 1.) from -5 deg C to 0 deg C, 30 min, 2.) RT, 3 h 3: 0.21 g / ethanol; H2O / 2 h / Heating View Scheme
参考文献
Glen, Robert C.; Martin, Graeme R.; Hill, Alan P.; Hyde, Richard M.; Woollard, Patrick M.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 18 p. 3566 - 3580
反应条件
hydrogenchloride; hydrogen; palladium on activated charcoal in ethanol P=760 Torr; Ambient temperature;
参考文献
Moloney, Gerard P.; Robertson, Alan D.; Martin, Graeme R.; MacLennan, Steven; Mathews, Neil; Dodsworth, Susan; Sang, Pang Yih; Knight, Cameron; Glen, Robert
Journal of Medicinal Chemistry, 1997 , vol. 40, # 15 p. 2347 - 2362
反应条件
1: 79 percent / H2, aq. HCl / 10percent Pd/C / ethanol / 760 Torr / Ambient temperature
2: conc. aq. HCl, NaNO2 / 0.5 h / 0 °C
3: 1.) aq. KOH, 3.) aq. HCl
4: polyphosphoric ester / CHCl3 / 8 h / Heating
View Scheme
参考文献
Moloney, Gerard P.; Robertson, Alan D.; Martin, Graeme R.; MacLennan, Steven; Mathews, Neil; Dodsworth, Susan; Sang, Pang Yih; Knight, Cameron; Glen, Robert
Journal of Medicinal Chemistry, 1997 , vol. 40, # 15 p. 2347 - 2362